Williams L L, O'Dougherty M M, Wright F S, Bobulski R J, Horrocks L A
Neurology. 1986 Sep;36(9):1200-5. doi: 10.1212/wnl.36.9.1200.
Twenty patients with type I Charcot-Marie-Tooth disease received dietary supplementation with the essential fatty acids (EFA), linoleic and gamma-linolenic acids, and vitamin E. A 3-month blinded trial of placebo (paraffin oil and vitamin E, 81.6 IU/d) was followed by 1 year of 3 grams daily of EFA and vitamin E. Serum fatty acid values doubled, but total esterified fatty acid proportions did not change. Arachidonic acid proportions correlated with the amount of prostaglandin-mediated lymphocyte suppression measured at the same times. Improvement demonstrated at the end of the placebo period by neuropsychological tests and neurologic examination was maintained during the 1 year of EFA supplementation. This effect may reflect a membrane stabilization benefit of vitamin E.
20例I型夏科-马里-图斯病患者接受了必需脂肪酸（EFA）、亚油酸和γ-亚麻酸以及维生素E的膳食补充。先进行了为期3个月的安慰剂（石蜡油和维生素E，81.6 IU/天）双盲试验，随后是为期1年的每天3克EFA和维生素E的补充。血清脂肪酸值翻倍，但总酯化脂肪酸比例未改变。花生四烯酸比例与同期测量的前列腺素介导的淋巴细胞抑制量相关。安慰剂期结束时通过神经心理学测试和神经系统检查显示的改善在EFA补充的1年期间得以维持。这种效应可能反映了维生素E对膜的稳定作用。
