Williams L L, Doody D M, Horrocks L A
Department of Pediatrics, Ohio State University College of Medicine, Columbus.
Lipids. 1988 Oct;23(10):981-8. doi: 10.1007/BF02536347.
Because abnormal serum fatty acid (FA) proportions had been found at three months after infectious mononucleosis (IM) in a pilot study, serum total FA profiles of 20 normal college students were measured at monthly intervals for one year following an acute Epstein-Barr virus (EBV) infection. Below normal proportions of arachidonic acid and a reversal of the usual serum ratio of linoleic and oleic acids were maximal during the third month after acute IM. These FA abnormalities coincided with the symptom of increased physical malaise, despite apparent clinical recovery, common after IM. Persistence of low linoleic acid content beyond six months postinfection occurred in all seven students who showed continued clinical symptoms. Estimation of FA enzyme activities over the post-IM year suggested that FA elongation function was normal, but that FA desaturation enzyme activities were lower than normal, particularly early after EBV infection. An inability of the host to normalize the serum total linoleic/oleic acid ratio may parallel a delayed recovery from EBV infection and may offer insight into its pathogenesis.
在一项初步研究中发现，传染性单核细胞增多症（IM）三个月后血清脂肪酸（FA）比例异常，因此对20名正常大学生在急性爱泼斯坦-巴尔病毒（EBV）感染后的一年里每月测量其血清总脂肪酸谱。急性IM后第三个月，花生四烯酸比例低于正常水平，亚油酸与油酸的血清常见比例发生逆转，且达到最大值。尽管临床已明显康复，但这些FA异常与IM后常见的身体不适加剧症状同时出现。在所有出现持续临床症状的7名学生中，感染后六个月以上亚油酸含量持续偏低。对IM后一年的FA酶活性评估表明，FA延长功能正常，但FA去饱和酶活性低于正常水平，尤其是在EBV感染后早期。宿主无法使血清总亚油酸/油酸比例恢复正常，可能与EBV感染恢复延迟同时出现，并可能为其发病机制提供线索。
