Shenoy Abhishek, Schulman Allison R
Division of Gastroenterology and Hepatology, University of Michigan, Michigan Medicine, Ann Arbor, MI, USA.
Department of Surgery, University of Michigan, Michigan Medicine, Ann Arbor, MI, USA.
Gastroenterol Rep (Oxf). 2023 Jul 21;11:goad043. doi: 10.1093/gastro/goad043. eCollection 2023.
The obesity epidemic in the USA and worldwide is well documented and continues to grow. Endoscopic metabolic and bariatric therapies may offer a less invasive approach than surgical intervention. This article will review advances in endobariatrics over the last several decades, addressing the past and current state of bariatric and metabolic endoscopy. Food and Drug Administration-cleared devices and interventions currently under investigation are described including gastric devices, gastric remodeling procedures, small-bowel devices, duodenal ablation, as well as procedures to address weight regain after bariatric surgery. Future studies evaluating gastric and duodenal combination therapy, adjunctive pharmacotherapy, as well as individualized precision-health algorithms are underway.
美国及全球的肥胖流行情况有充分记录且仍在持续发展。内镜下代谢和减肥疗法可能提供一种比手术干预侵入性更小的方法。本文将回顾过去几十年间内镜减肥领域的进展，阐述减肥与代谢内镜的过去及现状。文中描述了已获美国食品药品监督管理局批准的设备以及目前正在研究的干预措施，包括胃部设备、胃重塑手术、小肠设备、十二指肠消融，以及减肥手术后体重反弹的应对措施。评估胃和十二指肠联合治疗、辅助药物治疗以及个性化精准健康算法的未来研究正在进行中。
