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（蜘蛛目：Theridiidae）幼体和成虫的免疫刺激。对外来物体和 感染的损伤免疫反应。

Immunostimulation of (Araneae: Theridiidae) in juvenile and adult stages. Immunity reactions to injury with foreign body and infection.

机构信息

University of Silesia, Katowice, Poland.

出版信息

PeerJ. 2023 Jul 17;11:e15337. doi: 10.7717/peerj.15337. eCollection 2023.

DOI:10.7717/peerj.15337
PMID:37483985
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10358339/
Abstract

To assess the immune potential of spiders, in the present study juvenile and adult females of were exposed to infection, injury by a nylon monofilament and a combination of both. The expression level of selected immune-related genes: defensin 1 (Pt), lysozyme 1 (Pt), lysozyme C (Pt), lysozyme M1 (Pt), autophagy-related protein 101 (Pt), dynamin (Pt) and heat shock proteins (HSP70) (Pt, Pt, Pt), production of lysozyme and HSP70 proteins, and hemocytes viability were measured. The obtained results indicated expression of the lysozyme, autophagy-related protein and HSP70 genes in both ontogenetic stages of . It has been also shown that the simultaneous action of mechanical and biological factors causes higher level of lysozyme and HSP70, cell apoptosis intensity and lower level of hemocytes viability than in the case of exposure to a single immunostimulant. Moreover, mature females showed stronger early immune responses compared to juveniles.

摘要

为了评估蜘蛛的免疫潜力，本研究中，幼年和成年雌性 被暴露于 感染、尼龙单丝损伤以及两者的组合中。选择的免疫相关基因的表达水平：防御素 1（Pt）、溶菌酶 1（Pt）、溶菌酶 C（Pt）、溶菌酶 M1（Pt）、自噬相关蛋白 101（Pt）、动力蛋白（Pt）和热休克蛋白（HSP70）（Pt、Pt、Pt）、溶菌酶和 HSP70 蛋白的产生以及血淋巴细胞活力进行了测量。研究结果表明，在 的两个发育阶段均表达溶菌酶、自噬相关蛋白和 HSP70 基因。此外，与单一免疫刺激物暴露相比，机械和生物因素的同时作用导致溶菌酶和 HSP70 水平升高、细胞凋亡强度增加和血淋巴细胞活力降低。而且，成熟雌蛛比幼蛛表现出更强的早期免疫反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e910/10358339/0ae4a1f6a17d/peerj-11-15337-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e910/10358339/0cc843de1dc0/peerj-11-15337-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e910/10358339/23079fa0a42b/peerj-11-15337-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e910/10358339/7d27126c5133/peerj-11-15337-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e910/10358339/62b178ff2198/peerj-11-15337-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e910/10358339/8d485689a87a/peerj-11-15337-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e910/10358339/0ae4a1f6a17d/peerj-11-15337-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e910/10358339/0cc843de1dc0/peerj-11-15337-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e910/10358339/23079fa0a42b/peerj-11-15337-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e910/10358339/7d27126c5133/peerj-11-15337-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e910/10358339/62b178ff2198/peerj-11-15337-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e910/10358339/8d485689a87a/peerj-11-15337-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e910/10358339/0ae4a1f6a17d/peerj-11-15337-g006.jpg

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