Feng Limei, Yang Hongjun, Zhang Suxian, Xu Li
Department of Pharmacy, The Second Affiliated Hospital of Kunming Medical University, Kunming 650101, China.
Department of Gynecology, The Second Affiliated Hospital of Kunming Medical University, Kunming 650101, China.
Heliyon. 2023 Jun 1;9(6):e16623. doi: 10.1016/j.heliyon.2023.e16623. eCollection 2023 Jun.
In addition to the pharmacological effects of extracts (PAEs), including their antitumor, hepatic protection, antioxidant, antibacterial, anti-inflammatory, and tissue regeneration characteristics, their mucosal restorative effects have also attracted significant attention. The mucosa serves as a "gateway" into the body and its functions include the surveillance and clearance of bacteria and pathogens; it also has the immunological function of acquiring beneficial antigens from the external environment and removing non-beneficial ones, a mechanism controlled by the mucosal immune system. In the present study, the relevant modern research literature on the mucosal restorative effect of PAEs was reviewed via a summarization of its restorative effects on respiratory, digestive, dermal, and genitourinary mucosa. The aim of doing so was to present a comprehensive understanding of the mucosal restorative effect of PAEs and their related mechanisms and to provide a reference for their further development and clinical application.
除了提取物（邻苯二甲酸酯，PAEs）的药理作用，包括其抗肿瘤、肝脏保护、抗氧化、抗菌、抗炎和组织再生特性外，它们的黏膜修复作用也引起了极大关注。黏膜作为身体的“门户”，其功能包括监测和清除细菌及病原体；它还具有从外部环境获取有益抗原并清除非有益抗原的免疫功能，这一机制由黏膜免疫系统控制。在本研究中，通过总结PAEs对呼吸道、消化道、皮肤和泌尿生殖黏膜的修复作用，综述了关于PAEs黏膜修复作用的相关现代研究文献。这样做的目的是全面了解PAEs的黏膜修复作用及其相关机制，并为其进一步开发和临床应用提供参考。
