舒必利的急性和重复给药会改变大鼠脑内甲硫氨酸脑啡肽和亮氨酸脑啡肽的含量。
Acute and repeated administration of sulpiride alters Met-and Leu-enkephalin content of rat brain.
作者信息
De Ceballos M L, Jenner P, Marsden C D
出版信息
Neurosci Lett. 1986 Aug 4;68(3):322-6. doi: 10.1016/0304-3940(86)90510-0.
Following acute administration of sulpiride (100 mg/kg, i.p.), Met-enkephalin levels were increased in striatum but decreased in substantia nigra and nucleus accumbens. No effect was observed in hypothalamus or frontal cortex. In contrast, Leu-enkephalin content was decreased in the nucleus accumbens but not elsewhere. Administration of sulpiride (10 or 100 mg/kg, i.p.) for 21 days, followed by 2 days drug withdrawal, caused a dose-dependent increase in Met-enkephalin in nucleus accumbens but decreases in hypothalamus and frontal cortex. No change was observed in the striatum or substantia nigra. Repeated sulpiride administration caused a decrease in Leu-enkephalin content of the hypothalamus and cortex but not elsewhere.
急性注射舒必利（100毫克/千克，腹腔注射）后，纹状体内的甲硫氨酸脑啡肽水平升高，但黑质和伏隔核中的水平降低。下丘脑或额叶皮质未观察到影响。相比之下，伏隔核中的亮氨酸脑啡肽含量降低，但其他部位未降低。连续21天注射舒必利（10或100毫克/千克，腹腔注射），随后停药2天，导致伏隔核中甲硫氨酸脑啡肽呈剂量依赖性增加，但下丘脑和额叶皮质中的含量降低。纹状体或黑质未观察到变化。重复注射舒必利导致下丘脑和皮质中的亮氨酸脑啡肽含量降低，但其他部位未降低。
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