De Ceballos M L, Jenner P, Marsden C D
Neurosci Lett. 1986 Aug 4;68(3):322-6. doi: 10.1016/0304-3940(86)90510-0.
Following acute administration of sulpiride (100 mg/kg, i.p.), Met-enkephalin levels were increased in striatum but decreased in substantia nigra and nucleus accumbens. No effect was observed in hypothalamus or frontal cortex. In contrast, Leu-enkephalin content was decreased in the nucleus accumbens but not elsewhere. Administration of sulpiride (10 or 100 mg/kg, i.p.) for 21 days, followed by 2 days drug withdrawal, caused a dose-dependent increase in Met-enkephalin in nucleus accumbens but decreases in hypothalamus and frontal cortex. No change was observed in the striatum or substantia nigra. Repeated sulpiride administration caused a decrease in Leu-enkephalin content of the hypothalamus and cortex but not elsewhere.
急性注射舒必利（100毫克/千克，腹腔注射）后，纹状体内的甲硫氨酸脑啡肽水平升高，但黑质和伏隔核中的水平降低。下丘脑或额叶皮质未观察到影响。相比之下，伏隔核中的亮氨酸脑啡肽含量降低，但其他部位未降低。连续21天注射舒必利（10或100毫克/千克，腹腔注射），随后停药2天，导致伏隔核中甲硫氨酸脑啡肽呈剂量依赖性增加，但下丘脑和额叶皮质中的含量降低。纹状体或黑质未观察到变化。重复注射舒必利导致下丘脑和皮质中的亮氨酸脑啡肽含量降低，但其他部位未降低。
