Doğan Kaya Sibel, Taşçı Erdal, Kırali Kaan
Department of Infectious Diseases and Clinical Microbiology, Koşuyolu High Specialization Training and Research Hospital, Istanbul, Türkiye.
Turk Gogus Kalp Damar Cerrahisi Derg. 2023 Apr 28;31(2):269-274. doi: 10.5606/tgkdc.dergisi.2023.23489. eCollection 2023 Apr.
This study aims to evaluate the etiology and outcomes of donor-derived bacterial infections in patients undergoing lung transplantation.
Between January 2013 and December 2017, a total of 71 lung transplant recipients (56 males, 15 females; median age: 43.3 years) were retrospectively analyzed. The diagnosis of donor-derived bacterial infection was defined as the isolation of the same bacteria with the same antibiotic susceptibility patterns in a lung sample of donor and in one sample obtained from patients after transplantation and the presence of clinical evidence of infection.
Ten (14%) patients were found to have donor-derived bacterial infection. Acinetobacter baumannii was found in three, Pseudomonas aeruginosa in three, Klebsiella pneumoniae in one, Enterobacter cloacae in one, Staphylococcus aureus in one, and both Klebsiella pneumoniae and Acinetobacter baumannii in one patient. Twenty-four of lung-transplant recipients and four patients with donor-derived infection died.
Lung transplants are usually performed in hospitalized patients or in those admitted to the intensive care unit. These patients commonly experience infection and colonization with resistant microorganisms.
本研究旨在评估肺移植患者供体来源细菌感染的病因及结局。
回顾性分析2013年1月至2017年12月期间的71例肺移植受者（56例男性，15例女性；中位年龄：43.3岁）。供体来源细菌感染的诊断定义为在供体的肺样本和移植后从患者获得的一个样本中分离出具有相同抗生素敏感性模式的相同细菌，且存在感染的临床证据。
10例（14%）患者被发现存在供体来源细菌感染。其中3例为鲍曼不动杆菌，3例为铜绿假单胞菌，1例为肺炎克雷伯菌，1例为阴沟肠杆菌，1例为金黄色葡萄球菌，1例患者同时感染肺炎克雷伯菌和鲍曼不动杆菌。24例肺移植受者及4例供体来源感染患者死亡。
肺移植通常在住院患者或入住重症监护病房的患者中进行。这些患者通常会经历耐药微生物的感染和定植。
