慢性甲基苯丙胺和氟哌啶醇治疗后大鼠纹状体终扣的形态学变化。

Morphological changes in rat striatal boutons after chronic methamphetamine and haloperidol treatment.

作者信息

Ihara Y, Sato M, Otsuki S, Kaiya H, Namba M

出版信息

Neurosci Res. 1986 Jul;3(5):403-10. doi: 10.1016/0168-0102(86)90032-5.

Abstract

Dopaminergic (DA) synaptic boutons were identified in rat striatum with an electron microscopic histochemical method. In rats which developed behavioral hypersensitivity after treatment with methamphetamine (MAP) for about 2 weeks, significantly fewer DA boutons were found. This effect was specific to DA boutons without mitochondria and was not seen in boutons with mitochondria. The density of granular synaptic vesicles in DA boutons, however, did not change significantly. These morphological changes would represent a high capability of nerve cells to reorganize synaptic connections under altered chemical environments, but they could not be related uniquely to behavioral hypersensitivity, as similar effects were observed in rats treated with haloperidol which did not develop behavioral hypersensitivity. Peculiarly, the effects of MAP treatment on both behavior and DA boutons were prevented by combined administration of haloperidol.

摘要

采用电子显微镜组织化学方法在大鼠纹状体中鉴定出多巴胺能（DA）突触小体。在用甲基苯丙胺（MAP）处理约2周后出现行为超敏反应的大鼠中，发现DA突触小体明显减少。这种效应是DA无线粒体突触小体所特有的，在线粒体突触小体中未观察到。然而，DA突触小体中颗粒状突触小泡的密度没有显著变化。这些形态学变化表明神经细胞在化学环境改变时有很高的重组突触连接的能力，但它们与行为超敏反应并无唯一关联，因为在用未出现行为超敏反应的氟哌啶醇处理的大鼠中也观察到了类似的效应。奇怪的是，联合给予氟哌啶醇可预防MAP处理对行为和DA突触小体的影响。