Koshikawa N, Aoki S, Tomiyama K, Maruyama Y, Kobayashi M
Eur J Pharmacol. 1987 Jan 6;133(1):119-25. doi: 10.1016/0014-2999(87)90213-5.
Sulpiride injected into the dorsal striatum enhanced both methamphetamine- and apomorphine-induced gnawing but blocked both when injected into the ventral striatum. The hyperlocomotion produced by methamphetamine was reduced by sulpiride injected into the dorsal striatum. The DA, DOPAC and HVA concentrations in the ventral striatum were increased 60 min after the injection of sulpiride into the dorsal striatum. Possible reasons for the enhancement of methamphetamine-induced gnawing by sulpiride injected into the dorsal striatum are discussed.
注射到背侧纹状体的舒必利增强了甲基苯丙胺和阿扑吗啡诱导的啃咬行为，但注射到腹侧纹状体时则会阻断这两种行为。注射到背侧纹状体的舒必利降低了甲基苯丙胺产生的运动亢进。在向背侧纹状体注射舒必利60分钟后，腹侧纹状体中的多巴胺（DA）、3,4-二羟基苯乙酸（DOPAC）和高香草酸（HVA）浓度升高。本文讨论了注射到背侧纹状体的舒必利增强甲基苯丙胺诱导的啃咬行为的可能原因。
