Gül Sedat, Ahmed Adeenah F, McGraw Corey
Neurology, State University of New York Upstate Medical University, Syracuse, USA.
Cureus. 2023 Jun 20;15(6):e40689. doi: 10.7759/cureus.40689. eCollection 2023 Jun.
Multiple sclerosis (MS) is an autoimmune demyelinating disorder that disproportionately affects middle-aged women, and is capable of resulting in severe disability. However, the use of disease-modifying therapies has profoundly contributed to the improvement in the morbidity of the disorder. Diroximel fumarate (DRF) is a second-generation drug that has seen success in the treatment of relapsing-remitting MS (RRMS). While its relatively mild side effects of gastrointestinal discomfort are known, the less common complications are often missed in clinical settings. This includes a resulting susceptibility to opportunistic infections. In this case report, we describe a patient who experienced lymphopenia, recurrent yeast infections, and labial shingles while on the medication. This case highlights the side effects and the rare complications of the immunomodulator, DRF.
多发性硬化症（MS）是一种自身免疫性脱髓鞘疾病，对中年女性的影响尤为严重，且可能导致严重残疾。然而，疾病修正疗法的使用对该疾病发病率的改善起到了深远作用。富马酸二甲酯（DRF）是一种第二代药物，已成功用于治疗复发缓解型多发性硬化症（RRMS）。虽然其胃肠道不适等相对较轻的副作用是已知的，但临床环境中常常会漏诊一些不太常见的并发症。这包括由此导致的机会性感染易感性。在本病例报告中，我们描述了一名在服用该药物期间出现淋巴细胞减少、复发性酵母菌感染和唇部带状疱疹的患者。本病例突出了免疫调节剂DRF的副作用和罕见并发症。
