Pipitò Luca, Medaglia Alice, Russotto Irene, Bonura Silvia, Cascio Antonio
Department of Infectious and Tropical Diseases, Azienda Ospedaliera Universitaria Policlinico (AOUP) Paolo Giaccone, Palermo, ITA.
Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "G. D'Alessandro", University of Palermo, Palermo, ITA.
Cureus. 2023 Jun 22;15(6):e40776. doi: 10.7759/cureus.40776. eCollection 2023 Jun.
Multisystem inflammatory syndrome (MIS) is a new and rare complication of COVID-19 that usually occurs in children. An increasing number of cases of MIS in adults are described in the literature. The condition is associated with high mortality, and treatment is non-standardized. Clinical pictures are heterogeneous, and diagnosis is very challenging. Here we describe a case of MIS in a 60-year-old man with previous follicular lymphoma treated with obinutuzumab and recent SARS-CoV-2 infections. He complained of an unknown fever and developed pancytopenia during the hospitalization, associated with a general clinical worsening. The patient was successfully treated with intravenous immunoglobulin and steroids.
多系统炎症综合征（MIS）是新型冠状病毒肺炎（COVID-19）一种新的罕见并发症，通常发生于儿童。文献中描述的成人MIS病例数量日益增多。该病症与高死亡率相关，且治疗未标准化。临床表现各异，诊断极具挑战性。在此，我们描述一例60岁男性的MIS病例，该患者既往患有滤泡性淋巴瘤，接受过奥妥珠单抗治疗，近期感染了严重急性呼吸综合征冠状病毒2（SARS-CoV-2）。他主诉不明原因发热，住院期间出现全血细胞减少，并伴有全身临床状况恶化。该患者通过静脉注射免疫球蛋白和类固醇成功治愈。
