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病例报告:经皮冠状动脉介入治疗后发生A型主动脉夹层合并心肌梗死患者的手术联合体外膜肺氧合治疗

Case report: Surgery combined with extracorporeal membrane oxygenation for a patient with type A aortic dissection complicated with myocardial infarction after percutaneous coronary intervention.

作者信息

Yu Junjian, Yu Wenbo, Zeng Hui, Gao Jianfeng, Xiong Jianxian

机构信息

Department of Cardiac and Vascular Surgery, The First Affiliated Hospital of Gannan Medical University, Ganzhou, China.

The First Clinical Medical College of Gannan Medical University, Ganzhou, China.

出版信息

Front Cardiovasc Med. 2023 Jul 7;10:1205373. doi: 10.3389/fcvm.2023.1205373. eCollection 2023.

Abstract

BACKGROUND

Aortic dissection (AD) is a severe cardiovascular disease characterized by aortic rupture, aortic valve insufficiency, aortic branch lumen stenosis, and occlusion. Acute ST-segment elevation myocardial infarction may be the primary manifestation when aortic dissection affects the coronary artery, leading to delayed or missed diagnosis of aortic dissection, and preventing patients from receiving timely and comprehensive treatment. Simultaneous aortic repair and coronary artery bypass grafting surgery are controversial because of their high mortality rates. Personalized and optimal treatment plans for patients should be taken seriously based on their different conditions and treatment options.

CASE PRESENTATION

A 42-year-old man who experienced 1 h of persistent precordialgia was admitted to a local second-level hospital for emergency treatment. Electrocardiogram (ECG) showed evidence of ST-segment elevation, and myocardial enzyme levels were CK-MB 18.35 ng/ml and troponin 0.42 ng/ml. The patient was treated for acute myocardial infarction (AMI) and urgently sent to the interventional catheter room. Coronary angiography showed stenosis of the starting part of the right coronary artery trunk. Thus, stent implantation was performed, and the stenosis section recovered patency; however, postoperative precordialgia was not alleviated. Computed tomography angiography (CTA) revealed a type A AD. The patient was immediately transferred to a higher-level hospital, underwent emergency surgery with cardiopulmonary bypass (CPB) ascending aorta replacement, SUN's procedure (total arch replacement and stented elephant trunk implantation), and simultaneous implantation of extracorporeal membrane oxygenation (ECMO), and regained consciousness within intensive care unit care. ECMO was discontinued when hemodynamics stabilized. The patient ultimately recovered well and was discharged.

CONCLUSION

This case demonstrated that precordialgia is not limited to myocardial infarction but may also be accompanied by aortic dissection. Percutaneous coronary intervention (PCI) can timely and effectively restore coronary artery perfusion, strive for the opportunity of aortic repair surgery, and can overcome pump failure caused by myocardial infarction, cardiopulmonary bypass, heart block time, and myocardial ischemia-reperfusion injury. Personalized treatment is crucial for patients with complex type A aortic dissection.

摘要

背景

主动脉夹层(AD)是一种严重的心血管疾病,其特征为主动脉破裂、主动脉瓣关闭不全、主动脉分支管腔狭窄和闭塞。当主动脉夹层累及冠状动脉时,急性ST段抬高型心肌梗死可能成为主要表现,从而导致主动脉夹层的诊断延迟或漏诊,使患者无法得到及时、全面的治疗。同时进行主动脉修复和冠状动脉旁路移植手术因其高死亡率而存在争议。应根据患者的不同病情和治疗选择,认真制定个性化的最佳治疗方案。

病例介绍

一名42岁男性因持续1小时的心前区疼痛入住当地二级医院急诊科。心电图(ECG)显示有ST段抬高迹象,心肌酶水平为肌酸激酶同工酶(CK-MB)18.35 ng/ml,肌钙蛋白0.42 ng/ml。该患者接受了急性心肌梗死(AMI)治疗,并紧急送往介入导管室。冠状动脉造影显示右冠状动脉主干起始部狭窄。因此,进行了支架植入,狭窄段恢复通畅;然而,术后心前区疼痛并未缓解。计算机断层扫描血管造影(CTA)显示为A型主动脉夹层。患者立即被转至上级医院,接受了体外循环(CPB)升主动脉置换、孙氏手术(全弓置换及支架象鼻植入)的急诊手术,并同时植入体外膜肺氧合(ECMO),在重症监护病房护理期间恢复意识。血流动力学稳定后停用ECMO。患者最终恢复良好并出院。

结论

该病例表明,心前区疼痛不仅限于心肌梗死,也可能伴有主动脉夹层。经皮冠状动脉介入治疗(PCI)能够及时、有效地恢复冠状动脉灌注,争取主动脉修复手术的时机,并可克服心肌梗死、体外循环、心脏停搏时间及心肌缺血再灌注损伤导致的泵衰竭。对于复杂A型主动脉夹层患者,个性化治疗至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8404/10360360/90b753815387/fcvm-10-1205373-g001.jpg

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