Sible Isabel J, Yoo Hyun Joo, Min Jungwon, Nashiro Kaoru, Chang Catie, Nation Daniel A, Mather Mara
Department of Psychology, University of Southern California, Los Angeles, CA 90089, USA.
Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA.
Aging Brain. 2023 Jul 11;4:100085. doi: 10.1016/j.nbas.2023.100085. eCollection 2023.
Blood pressure variability (BPV), independent of mean blood pressure levels, is associated with cerebrovascular disease burden on MRI and postmortem evaluation. However, less is known about relationships with markers of cerebrovascular dysfunction, such as diminished spontaneous brain activity as measured by the amplitude of low frequency fluctuations (ALFF), especially in brain regions with vascular and neuronal vulnerability in aging. We investigated the relationship between short-term BPV and concurrent regional ALFF from resting state fMRI in a sample of community-dwelling older adults ( = 44) and healthy younger adults ( = 49). In older adults, elevated systolic BPV was associated with lower ALFF in widespread medial temporal regions and the anterior cingulate cortex. Higher systolic BPV in younger adults was also related to lower ALFF in the medial temporal lobe, albeit in fewer subregions, and the amygdala. There were no significant associations between systolic BPV and ALFF across the right/left whole brain or in the insular cortex in either group. Findings suggest a possible regional vulnerability to cerebrovascular dysfunction and short-term fluctuations in blood pressure. BPV may be an understudied risk factor for cerebrovascular changes in aging.
血压变异性（BPV）独立于平均血压水平，与MRI和尸检评估中的脑血管疾病负担相关。然而，关于其与脑血管功能障碍标志物的关系，如通过低频波动幅度（ALFF）测量的自发性脑活动减弱，人们了解较少，尤其是在衰老过程中具有血管和神经元易损性的脑区。我们在一组社区居住的老年人（n = 44）和健康年轻人（n = 49）样本中，研究了静息态功能磁共振成像中短期BPV与同期局部ALFF之间的关系。在老年人中，收缩压BPV升高与广泛的内侧颞叶区域和前扣带回皮质的较低ALFF相关。在年轻人中，较高的收缩压BPV也与内侧颞叶（尽管子区域较少）和杏仁核的较低ALFF有关。在两组中，收缩压BPV与右侧/左侧全脑或岛叶皮质的ALFF之间均无显著关联。研究结果表明，可能存在对脑血管功能障碍和血压短期波动的区域易损性。BPV可能是衰老过程中脑血管变化的一个研究不足的危险因素。
