Department for Dermatology, University Hospital Regensburg, Regensburg, Germany.
J Dtsch Dermatol Ges. 2023 Aug;21(8):882-897. doi: 10.1111/ddg.15126. Epub 2023 Jul 24.
Despite the development of highly effective biologics for skin diseases such as psoriasis or atopic dermatitis, UVA and UVB therapy, alone or in combination, are still essential components of various guidelines. Phototherapy is not only a first-line treatment and highly effective for a number of skin diseases, but is also economical and has few side effects. The targeted use of UVA and UVB, if necessary, in combination with the photosensitizer psoralen in the context of PUVA therapy, enables the dermatologist to effectively treat a wide variety of skin diseases. Indications for phototherapy include epidermal diseases such as atopic dermatitis, psoriasis and vitiligo, as well as photodermatoses, mycosis fungoides, graft-versus-host disease and deep dermal diseases such as scleroderma. This article reviews the physical principles, molecular mechanisms, current treatment regimens, and individual indications for phototherapy and photochemotherapy.
尽管已经开发出了针对银屑病或特应性皮炎等皮肤病的高效生物制剂，但 UVA 和 UVB 疗法，无论是单独使用还是联合使用，仍然是各种指南的重要组成部分。光疗不仅是一种一线治疗方法，对许多皮肤病都非常有效，而且经济实惠，副作用也很少。在必要时，有针对性地使用 UVA 和 UVB，并结合光化学疗法中的补骨脂素作为光敏剂，使皮肤科医生能够有效地治疗各种皮肤病。光疗的适应证包括表皮疾病，如特应性皮炎、银屑病和白癜风，以及光发性疾病、蕈样肉芽肿、移植物抗宿主病和真皮深部疾病，如硬皮病。本文综述了光疗和光化学疗法的物理原理、分子机制、当前治疗方案以及个体化适应证。
