Philippi Hanna, Sommerfeld Vera, Windisch Wilhelm, Olukosi Oluyinka Abiona, Monteiro Alessandra, Rodehutscord Markus
Institute of Animal Science, University of Hohenheim, Stuttgart, Germany.
Chair of Animal Nutrition, TUM School of Life Sciences, Technical University of Munich, Freising, Germany.
J Sci Food Agric. 2023 Dec;103(15):7333-7342. doi: 10.1002/jsfa.12879. Epub 2023 Aug 10.
Phytase supplementation is gaining importance in animal nutrition because of its effect on phosphorus (P) digestibility and the increasing relevance of P for sustainable production. The potential inhibitors of phytase efficacy and phytate degradation, such as calcium (Ca) and zinc (Zn), have been a subject of intense research. This review focuses on the interactions of Zn with phytate and phytase in the digestive tract of poultry and pigs, with an emphasis on the effects of Zn supplementation on phytase efficacy and P digestibility. In vitro studies have shown the inhibitory effect of Zn on phytase efficacy. However, relevant in vivo studies are scarce and do not show consistent results for poultry and pigs. The results could be influenced by different factors, such as diet composition, amount of Zn supplement, mineral concentrations, and phytase supplementation, which limit the comparability of studies. The chosen response criteria to measure phytase efficacy, which is mainly tibia ash, could also influence the results. Compared to poultry, the literature findings are somewhat more conclusive in pigs, where pharmacological Zn doses (≥ 1000 mg kg Zn) appear to reduce P digestibility. To appropriately evaluate the effects of non-pharmacological Zn doses, further studies are needed that provide comprehensive information on their experimental setup and include measurements of gastrointestinal phytate degradation to better understand the mechanisms associated with Zn and phytase supplements. © 2023 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
由于植酸酶对磷（P）消化率的影响以及磷对可持续生产的相关性日益增加，补充植酸酶在动物营养中变得越来越重要。植酸酶功效和植酸盐降解的潜在抑制剂，如钙（Ca）和锌（Zn），一直是深入研究的主题。本综述重点关注锌与植酸盐和植酸酶在家禽和猪消化道中的相互作用，重点是补充锌对植酸酶功效和磷消化率的影响。体外研究表明锌对植酸酶功效有抑制作用。然而，相关的体内研究很少，并且对家禽和猪的结果并不一致。结果可能受到不同因素的影响，如饮食组成、锌补充量、矿物质浓度和植酸酶补充量，这限制了研究的可比性。用于衡量植酸酶功效的选定反应标准（主要是胫骨灰分）也可能影响结果。与家禽相比，猪的文献研究结果更具决定性，在猪中，药理学剂量的锌（≥1000 mg/kg锌）似乎会降低磷的消化率。为了适当地评估非药理学剂量锌的影响，需要进一步的研究，这些研究提供有关其实验设置的全面信息，并包括胃肠道植酸盐降解的测量，以更好地了解与锌和植酸酶补充剂相关的机制。© 2023作者。《食品与农业科学杂志》由约翰·威利父子有限公司代表化学工业协会出版。
