Campbell University at Sampson Regional Medical Center, Clinton, North Carolina, U.S.A.
Department of Pathology, Campbell University Jerry M. Wallace School of Osteopathic Medicine, Lillington, North Carolina, U.S.A.
Ophthalmic Plast Reconstr Surg. 2023;39(6):e199-e202. doi: 10.1097/IOP.0000000000002465. Epub 2023 Jul 21.
The authors present the third example of an eccrine ductal carcinoma of the eyelid. A woman in her early 70s presented with a lesion of the central right lower eyelid margin in the vicinity where an actinic keratosis was diagnosed by biopsy 2.75 years previously. Her dermatologist and ophthalmologist monitored the area of actinic keratosis, and it was stable for 2.5 years until the area became ulcerated and thickened with the loss of eyelashes. A wedge resection disclosed a squamous cell carcinoma in situ and a separate eccrine ductal carcinoma. The eccrine ductal carcinoma had in situ tumor thickening, an eccrine duct component, and an invasive tumor infiltrating the tarsal plate and replacing the normal meibomian glands. The invasive eccrine ductal carcinoma only mildly thickened the tarsal plate and was most likely an incidental finding in a biopsy prompted by the squamous cell carcinoma in situ. The 5-year relative survival rate for malignant apocrine-eccrine tumors is approximately 97%, and our patient is alive and without evidence of local or distant tumor recurrence 5.5 years following the excision of her eyelid tumor.
作者呈现了第三例眼睑的汗腺导管癌的病例。一位 70 岁出头的女性因右侧下眼睑中央有一处病变就诊，此前 2.75 年前曾在此处活检诊断为光化性角化病。她的皮肤科医生和眼科医生一直在监测光化性角化病区域，该区域在 2.5 年内保持稳定，直到该区域出现溃疡和增厚，睫毛脱落。楔形切除术显示原位鳞状细胞癌和另一个单独的汗腺导管癌。汗腺导管癌有原位肿瘤增厚、汗腺导管成分和侵袭性肿瘤浸润睑板并取代正常的睑板腺。侵袭性汗腺导管癌仅轻度增厚睑板，在原位鳞状细胞癌的情况下，活检可能是偶然发现。恶性大汗腺-汗腺肿瘤的 5 年相对生存率约为 97%，我们的患者在切除眼睑肿瘤后 5.5 年仍存活且无局部或远处肿瘤复发的证据。
