Sivanandan Sudheesh T, Nair Divya K, Namboothiri Irishi N N
Department of Chemistry, Indian Institute of Technology Bombay, Mumbai 400 076, India.
Department of Chemistry, University of Nottingham, Nottingham, NG7 2RD, UK.
Org Biomol Chem. 2023 Aug 9;21(31):6243-6262. doi: 10.1039/d3ob00853c.
The Morita-Baylis-Hillman (MBH) and Rauhut-Currier (RC) adducts of nitroalkenes are important synthetic intermediates in organic synthesis. This review discusses the applications of different MBH and RC adducts of nitroalkenes such as MBH alcohols, acetates, bromides and hydrazinonitroalkenes as well as ketoalkylnitroalkenes in the synthesis of complex molecules including carbocycles and heterocycles. It also covers the mechanistic aspects, including the key intermediates and the reaction pathways. Early reports on MBH and RC reactions of nitroalkenes and applications of the products were covered in previous reviews. The present review covers the reports that appeared in the timeline of 2015-2023.
硝基烯烃的森田-贝利斯-希尔曼（MBH）和劳胡特-库里尔（RC）加合物是有机合成中重要的合成中间体。本综述讨论了硝基烯烃不同的MBH和RC加合物，如MBH醇、乙酸酯、溴化物和肼基硝基烯烃以及酮烷基硝基烯烃在合成包括碳环和杂环的复杂分子中的应用。它还涵盖了机理方面，包括关键中间体和反应途径。之前的综述中涵盖了关于硝基烯烃的MBH和RC反应以及产物应用的早期报道。本综述涵盖了2015年至2023年期间出现的报道。
