有机催化的森田-贝利斯-希尔曼反应的最新进展与展望

Recent progress and prospects in the organocatalytic Morita-Baylis-Hillman reaction.

作者信息

Maneesha Mohammed, Haritha S H, Aneeja Thaipparambil, Anilkumar Gopinathan

机构信息

School of Chemical Sciences, Mahatma Gandhi University Priyadarsini Hills P. O. Kottayam Kerala 686560 India

Postgraduate Department of Chemistry, Sree Narayana College, Sivagiri Sreenivasapuram P. O., Varkala Thiruvananthapuram Kerala 695145 India.

出版信息

RSC Adv. 2024 May 8;14(21):14949-14963. doi: 10.1039/d4ra02369b. eCollection 2024 May 2.

DOI:10.1039/d4ra02369b

PMID:38720983

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11077279/

Abstract

The organocatalytic asymmetric Morita-Baylis-Hillman (MBH) reaction produces a significant carbon-carbon bond formation that involves the addition of α,β-unsaturated carbonyl compounds to activated alkenes to give α-methylene-β-hydroxycarbonyl compounds. Commercially available starting materials, excellent atom economy, mild reaction conditions, and flexible products are the major highlights of this method. In this review, we discuss the recent developments in the organocatalytic MBH reaction, covering literature from 2018 to 2023.

摘要

有机催化的不对称森田-贝利斯-希尔曼（MBH）反应能形成重要的碳-碳键，该反应涉及将α,β-不饱和羰基化合物加成到活性烯烃上，生成α-亚甲基-β-羟基羰基化合物。该方法的主要亮点包括起始原料可商购、原子经济性优异、反应条件温和以及产物具有灵活性。在本综述中，我们讨论了2018年至2023年期间有机催化MBH反应的最新进展。