Raji Elahe, Vahedian Vahid, Golshanrad Pezhman, Nahavandi Reza, Behshood Parisa, Soltani Nahal, Gharibi Mahdi, Rashidi Mohsen, Maroufi Nazila Fathi
Department of Biology, Shahrekord Branch, Islamic Azad University, Iran.
Department of Hematology, Transfusion Medicine and Cellular Therapy, Division of Hematology/oncology, Clinical Hospital, Faculty of Medicine, University of Sao Paulo (FMUSP-HC), Sao Paulo, Brazil; Department of Clinical Medicine, Laboratory of Medical Investigation in Pathogenesis and Targeted Therapy in Onco-Immuno-Hematology (LIM/31), Faculty of Medicine, University of Sao Paulo (FMUSP), Sao Paulo, Brazil.
Pathol Res Pract. 2023 Aug;248:154686. doi: 10.1016/j.prp.2023.154686. Epub 2023 Jul 13.
Galbanic acid (GBA), as a natural compound has potential anticancer properties. It has been documented that GBA shows promising therapeutic potential against various types of cancer, including breast, lung, colon, liver, and prostate cancer. Several mechanisms involve im anti-tumor effects of GBA include apoptosis induction, cell cycle arrest, inhibition of angiogenesis, suppression of metastasis, and modulation of immune responses. Furthermore, the synergistic effects of GBA along with chemotherapeutic agents led to has enhancing efficiency with reduction in toxicity. Moreover, GBA through antioxidant and anti-inflammatory properties possess indirect anti-tumor effects. In this review, we will summarize the anti-tumor effects of GBA acid along with involve mechanisms.
没食子酸（GBA）作为一种天然化合物具有潜在的抗癌特性。据记载，GBA对包括乳腺癌、肺癌、结肠癌、肝癌和前列腺癌在内的多种癌症显示出有前景的治疗潜力。GBA的抗肿瘤作用涉及的几种机制包括诱导凋亡、细胞周期阻滞、抑制血管生成、抑制转移以及调节免疫反应。此外，GBA与化疗药物的协同作用提高了疗效并降低了毒性。此外，GBA通过抗氧化和抗炎特性具有间接抗肿瘤作用。在本综述中，我们将总结GBA的抗肿瘤作用及其涉及的机制。
