Key Lab of Exercise and Health Sciences of Ministry of Education, Shanghai University of Sport, Shanghai 200438, China; Shanghai Key Lab of Human Performance, Shanghai University of Sport, Shanghai 200438, China.
Key Lab of Exercise and Health Sciences of Ministry of Education, Shanghai University of Sport, Shanghai 200438, China; Shanghai Key Lab of Human Performance, Shanghai University of Sport, Shanghai 200438, China.
Biomed Pharmacother. 2023 Sep;165:115191. doi: 10.1016/j.biopha.2023.115191. Epub 2023 Jul 22.
β-hydroxybutyrate (β-HB), the most abundant ketone body, is produced primarily in the liver and acts as a substitute energy fuel to provide energy to extrahepatic tissues in the event of hypoglycemia or glycogen depletion. We now have an improved understanding of β-HB as a signal molecule and epigenetic regulatory factor as a result of intensive research over the last ten years. Because β-HB regulates various physiological and pathological processes, it may have a potential role in the treatment of metabolic diseases. The liver is the most significant metabolic organ, and the part that β-HB plays in liver disorders is receiving increasing attention. In this review, we summarize the therapeutic effects of β-HB on liver diseases and its underlying mechanisms of action. Moreover, we explore the prospects of exogenous supplements and endogenous ketosis including fasting, caloric restriction (CR), ketogenic diet (KD), and exercise as adjuvant nutritional therapies to protect the liver from damage and provide insights and strategies for exploring the treatment of various liver diseases.
β-羟丁酸（β-HB）是最丰富的酮体，主要在肝脏中产生，作为替代能源燃料，在低血糖或糖原耗竭时为肝外组织提供能量。由于过去十年的深入研究，我们现在对β-HB 作为信号分子和表观遗传调节因子有了更好的理解。由于β-HB 调节各种生理和病理过程，它可能在代谢性疾病的治疗中具有潜在作用。肝脏是最重要的代谢器官，β-HB 在肝脏疾病中的作用正受到越来越多的关注。在这篇综述中，我们总结了β-HB 对肝脏疾病的治疗作用及其作用机制。此外，我们还探讨了外源性补充和内源性酮症（包括禁食、热量限制（CR）、生酮饮食（KD）和运动）作为辅助营养治疗来保护肝脏免受损伤的前景，并为探索治疗各种肝脏疾病提供了思路和策略。
