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酮体生成受损与代谢相关脂肪性肝病的关联。

Association between Impaired Ketogenesis and Metabolic-Associated Fatty Liver Disease.

机构信息

Division of Endocrinology and Metabolism, Department of Internal Medicine, Catholic Kwandong University College of Medicine, International St. Mary's Hospital, Incheon 22711, Republic of Korea.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.

出版信息

Biomolecules. 2023 Oct 11;13(10):1506. doi: 10.3390/biom13101506.

Abstract

Metabolic (dysfunction) associated fatty liver disease (MAFLD) is generally developed with excessive accumulation of lipids in the liver. Ketogenesis is an efficient pathway for the disposal of fatty acids in the liver and its metabolic benefits have been reported. In this review, we examined previous studies on the association between ketogenesis and MAFLD and reviewed the candidate mechanisms that can explain this association.

摘要

代谢(功能)相关脂肪性肝病(MAFLD)通常是由于肝脏内脂质过度积累而发展的。酮体生成是肝脏处理脂肪酸的有效途径,其代谢益处已有报道。在这篇综述中,我们检查了先前关于酮体生成与 MAFLD 之间关联的研究,并回顾了可以解释这种关联的候选机制。

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