Service de rhumatologie, université Angers, CHU d'Angers, Paris, France.
Department of Rheumatology, EULAR Center of Excellence, hôpital Cochin, Assistance publique-Hôpitaux de Paris, Paris University, Paris, France.
Joint Bone Spine. 2023 Dec;90(6):105619. doi: 10.1016/j.jbspin.2023.105619. Epub 2023 Jul 22.
Axial spondyloarthritis (axSpA) is the prototype of the spondyloarthritis spectrum. The involvement of T cells in its pathogenesis has long been suspected on the basis of the association with the major histocompatibility complex I molecule HLA-B27 and the pivotal role of interleukin 17 in the inflammatory mechanisms associated with the disease. Moreover, the presence of unconventional or "innate-like" T cells within the axial enthesis suggests an important role for these cells in the pathophysiology of the disease. In this review, we describe the characteristics and the interleukin 17 secretion capacity of the T-cell subsets identified in axSpA. We discuss the genetic and epigenetic mechanisms that support the alteration of T-cell functions and promote their activation in axSpA. We also discuss recent data on T cells that could explain the extra-articular manifestations of the SpA spectrum.
中轴型脊柱关节炎（axSpA）是脊柱关节炎谱的典型代表。基于与主要组织相容性复合体 I 分子 HLA-B27 的关联以及白细胞介素 17 在与疾病相关的炎症机制中的关键作用，人们早就怀疑 T 细胞在其发病机制中起作用。此外，在轴向附着点内存在非传统或“固有样”T 细胞表明这些细胞在疾病的病理生理学中起重要作用。在这篇综述中，我们描述了在 axSpA 中鉴定的 T 细胞亚群的特征和白细胞介素 17 分泌能力。我们讨论了支持 T 细胞功能改变和促进其在 axSpA 中激活的遗传和表观遗传机制。我们还讨论了最近关于 T 细胞的研究数据，这些数据可以解释 SpA 谱的关节外表现。
