State Key Laboratory of Component-based Chinese Medicine, Research Center of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, PR China; Haihe Laboratory of Modern Chinese Medicine, Tianjin, 301617, PR China.
The Second Hospital of Tianjin Medical University, Tianjin, 300211, PR China.
J Ethnopharmacol. 2024 Jan 10;318(Pt A):116952. doi: 10.1016/j.jep.2023.116952. Epub 2023 Jul 23.
Interstitial lung disease (ILD) is a chronic lung dysfunction disease with a poor prognosis and poor recovery. The clinically used therapeutic drugs, such as glucocorticoids and immunosuppressants, have no significant therapeutic effect and are accompanied with severe side effects. In recent years, considerable progress has been made in exploring and applying natural herb components for treating ILD. Traditional Chinese Medicine (TCM) possesses innate, non-toxic characteristics and offers advantages in preventing and treating pulmonary ailments. However, a comprehensive study of TCM on ILD therapy has not yet been reviewed.
This review aimed to provide a comprehensive summary of the monomer components, total extracts, and prescriptions of TCM for ILD therapy, elucidating their molecular mechanisms to serve as a reference in treating ILD.
The literature information was searched in the PubMed, Web of Science databases. The search keywords included 'interstitial lung disease', 'lung fibrosis' or 'pulmonary fibrosis', and 'traditional Chinese medicine', 'traditional herbal medicine', or 'herb medicine'.
The active components of single herbs, such as alkaloids, flavonoids, terpenoids, phenols, and quinones, have potential therapeutic effects on ILD. The active extracts and prescriptions were also summarized and analyzed. The herbs, Glycyrrhiza uralensis Fisch. (Gancao), Astragalus membranaceus Fisch. Bunge. (Huangqi) and Angelicasinensis (Oliv.) Diels (Danggui), play significant roles in the treatment of ILD. The mechanisms involve the inhibition of inflammatory factor release, anti-oxidative injury, and interference with collagen production, etc. CONCLUSION: This review examines the therapeutic potential of TCM for ILD and elucidates its molecular mechanisms, demonstrating that mitigating inflammation and oxidative stress, modulating the immune system, and promoting tissue repair are efficacious strategies for ILD therapy. The depth research will yield both theoretical and practical implications.
间质性肺病 (ILD) 是一种慢性肺功能障碍疾病,预后不良且恢复不佳。临床使用的治疗药物,如糖皮质激素和免疫抑制剂,疗效不显著,且伴有严重的副作用。近年来,在探索和应用天然草药成分治疗 ILD 方面取得了相当大的进展。中药 (TCM) 具有先天无毒的特点,在预防和治疗肺部疾病方面具有优势。然而,TCM 治疗 ILD 的综合研究尚未得到综述。
本综述旨在全面总结 TCM 治疗 ILD 的单体成分、总提取物和方剂,阐明其分子机制,为治疗 ILD 提供参考。
在 PubMed、Web of Science 数据库中检索文献信息。检索关键词包括“间质性肺病”、“肺纤维化”或“肺纤维化”以及“中药”、“传统草药”或“草药”。
单味草药的活性成分,如生物碱、黄酮类、萜类、酚类和醌类,对 ILD 具有潜在的治疗作用。还总结和分析了活性提取物和方剂。甘草 (Glycyrrhiza uralensis Fisch.)、黄芪 (Astragalus membranaceus Fisch. Bunge.) 和当归 (Angelicasinensis (Oliv.) Diels) 等草药在治疗 ILD 方面发挥着重要作用。其机制涉及抑制炎症因子释放、抗氧化损伤和干扰胶原生成等。
本综述考察了 TCM 治疗 ILD 的潜力,并阐明了其分子机制,表明减轻炎症和氧化应激、调节免疫系统和促进组织修复是治疗 ILD 的有效策略。深入研究将产生理论和实际意义。