School of Life Science and Food Engineering, Huaiyin Institute of Technology, Huai'an, Jiangsu 223003, China.
Faculty of Electronic Information Engineering, Huaiyin Institute of Technology, Huai'an, Jiangsu 223003, China.
Int J Biol Macromol. 2023 Sep 30;249:125964. doi: 10.1016/j.ijbiomac.2023.125964. Epub 2023 Jul 23.
Rhamnan sulfate, a rhamnose-rich sulfated polysaccharide, is present in the cell walls of green seaweed belonging to the genus Monostroma. This macromolecule demonstrates promising therapeutic properties, including anti-coagulant, thrombolytic, anti-viral, anti-obesity, and anti-inflammatory activities, which hold potential applications in food and medical industries. However, rhamnan sulfate has not garnered as much attention from researchers as other seaweed polysaccharides, including alginate, carrageenan, and fucoidan. This review discusses the extraction and purification techniques of rhamnan sulfate, delves into its chemical structures and related elucidation approaches, and provides an overview of its biological functions. Future research should focus on the structure-activity relationship of rhamnan sulfate and the industrial preparation of rhamnan sulfate with a specific homogeneous structure to facilitate its practical applications.
鼠李半乳糖醛酸聚糖硫酸酯是一种富含鼠李糖的硫酸多糖，存在于属于绿藻门丝藻属的绿藻细胞壁中。这种大分子具有有前途的治疗特性，包括抗凝血、溶栓、抗病毒、抗肥胖和抗炎活性，在食品和医疗行业有潜在的应用。然而，鼠李半乳糖醛酸聚糖硫酸酯并没有像其他海藻多糖（如藻酸盐、卡拉胶和褐藻糖胶）那样受到研究人员的关注。本文综述了鼠李半乳糖醛酸聚糖硫酸酯的提取和纯化技术，探讨了其化学结构和相关解析方法，并概述了其生物学功能。未来的研究应集中在鼠李半乳糖醛酸聚糖硫酸酯的结构-活性关系以及具有特定均一结构的鼠李半乳糖醛酸聚糖硫酸酯的工业制备上，以促进其实际应用。
