Wang Jing, Zeng Lili, Kong Lingping, Zhang Linlin, Chen Jun, Zhong Diansheng, Fan Yaguang
Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, China.
Department of Medical Oncology, Tianjin Medical University General Hospital, Tianjin 300052, China.
Zhongguo Fei Ai Za Zhi. 2023 Jun 20;26(6):473-478. doi: 10.3779/j.issn.1009-3419.2023.101.19.
Klotho gene was originally discovered as an anti-aging gene, Klotho protein encoded by Klotho gene is expressed in multiple human tissues, and its most prominent function is the regulation of phosphate homeostasis. Klotho protein possesses various activities, including inhibition of multiple signaling pathways, reducing oxidative stress and suppressing inflammation, and these activities are associated with cancer. Klotho protein is discovered as a universal tumor suppressor, and its expression is associated with tumorigenesis and prognosis of patients. Lung cancer is the most common malignancy tumor, and it is the leading cause of cancer deaths worldwide because of its high incidence and mortality. This article summarizes the research progress of the role of Klotho on pathogenesis, therapeutic effect and prognosis in lung cancer, in order to provide new biomarker and target for diagnosis, treatment and prognosis of lung cancer. .
klotho基因最初被发现是一种抗衰老基因，由klotho基因编码的klotho蛋白在多种人体组织中表达，其最显著的功能是调节磷酸盐稳态。klotho蛋白具有多种活性，包括抑制多种信号通路、减轻氧化应激和抑制炎症，这些活性都与癌症相关。klotho蛋白被发现是一种通用的肿瘤抑制因子，其表达与患者的肿瘤发生和预后相关。肺癌是最常见的恶性肿瘤，由于其高发病率和高死亡率，它是全球癌症死亡的主要原因。本文综述了klotho在肺癌发病机制、治疗效果和预后方面的研究进展，以期为肺癌的诊断、治疗和预后提供新的生物标志物和靶点。
