Trzeciak H I, Janas P, Herman Z S
Pol J Pharmacol Pharm. 1986 Mar-Apr;38(2):179-83.
Male Wistar rats were treated with imipramine hydrochloride (IMI) in a dose of 2 or 10 mg/kg/24 h in drinking water for 2 weeks, 1, 3 or 6 months. Two or 72 h after the final treatment forced swimming test was performed. It was shown that 2 h after the final dose of 10 mg/kg of IMI the immobility time was reduced following a period of 1-6 month treatment but not after 2 weeks of IMI administration. The dose of 2 mg/kg of IMI has not changed this type of behavior at any time after IMI treatment. After 24 h IMI (2 or 10 mg/kg) decreased the immobility of rats. This paper presents for the first time that also after long-term treatment with IMI the evident effect on the time of immobility in the rat forced swimming test occurs.
将雄性Wistar大鼠置于含2或10mg/kg/24h盐酸丙咪嗪（IMI）的饮用水中处理2周、1个月、3个月或6个月。在末次处理后2小时或72小时进行强迫游泳试验。结果显示，在给予10mg/kg IMI末次剂量后2小时，经过1 - 6个月的处理，大鼠的不动时间缩短，但在给予IMI 2周后未出现此现象。2mg/kg剂量的IMI在处理后的任何时间均未改变这种行为类型。给予IMI（2或10mg/kg）24小时后，大鼠的不动时间减少。本文首次提出，长期给予IMI后，在大鼠强迫游泳试验中对不动时间也有明显影响。
