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Stress granules: friend or foe in neurodegenerative disorders?

作者信息

Xu Shanshan, Dantuma Nico P

机构信息

Department of Cell and Molecular Biology (CMB), Karolinska Institutet, Solnavägen 9, S-17165 Stockholm, Sweden.

出版信息

Neural Regen Res. 2024 Feb;19(2):403-404. doi: 10.4103/1673-5374.379044.

DOI:10.4103/1673-5374.379044
PMID:37488902
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10503615/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5cd/10503615/a895448ddaa9/NRR-19-403-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5cd/10503615/a895448ddaa9/NRR-19-403-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5cd/10503615/a895448ddaa9/NRR-19-403-g001.jpg

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本文引用的文献

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Neuronal stress granules as dynamic microcompartments: current concepts and open questions.神经元应激颗粒作为动态的微区室:当前的概念和未解决的问题。
Biol Chem. 2023 Feb 14;404(5):491-498. doi: 10.1515/hsz-2022-0302. Print 2023 Apr 25.
2
Cytosolic stress granules relieve the ubiquitin-proteasome system in the nuclear compartment.细胞质应激颗粒可减轻核区的泛素-蛋白酶体系统负担。
EMBO J. 2023 Feb 1;42(3):e111802. doi: 10.15252/embj.2022111802. Epub 2022 Dec 27.
3
Ubiquitination of G3BP1 mediates stress granule disassembly in a context-specific manner.
G3BP1 的泛素化以特定于上下文的方式介导应激颗粒的解体。
Science. 2021 Jun 25;372(6549):eabf6548. doi: 10.1126/science.abf6548. Epub 2021 Aug 5.
4
The Nuclear SUMO-Targeted Ubiquitin Quality Control Network Regulates the Dynamics of Cytoplasmic Stress Granules.核 SUMO 靶向泛素质量控制网络调节细胞质应激颗粒的动态变化。
Mol Cell. 2020 Jul 2;79(1):54-67.e7. doi: 10.1016/j.molcel.2020.05.017. Epub 2020 Jun 9.
5
The integrated stress response: From mechanism to disease.整体应激反应:从机制到疾病。
Science. 2020 Apr 24;368(6489). doi: 10.1126/science.aat5314.
6
The nucleolus functions as a phase-separated protein quality control compartment.核仁作为一个相分离的蛋白质质量控制隔室发挥功能。
Science. 2019 Jul 26;365(6451):342-347. doi: 10.1126/science.aaw9157. Epub 2019 Jul 11.
7
Defective ribosomal products challenge nuclear function by impairing nuclear condensate dynamics and immobilizing ubiquitin.核糖体产物缺陷通过损害核凝聚物动力学和固定泛素来挑战核功能。
EMBO J. 2019 Aug 1;38(15):e101341. doi: 10.15252/embj.2018101341. Epub 2019 Jul 4.
8
SUMOylation and the HSF1-Regulated Chaperone Network Converge to Promote Proteostasis in Response to Heat Shock.SUMOylation 和热休克因子 1 调节的伴侣蛋白网络的汇聚促进热休克后的蛋白质稳态。
Cell Rep. 2019 Jan 2;26(1):236-249.e4. doi: 10.1016/j.celrep.2018.12.027.
9
VCP/p97-Mediated Unfolding as a Principle in Protein Homeostasis and Signaling.VCP/p97 介导的展开作为蛋白质动态平衡和信号传导的原则。
Mol Cell. 2018 Jan 18;69(2):182-194. doi: 10.1016/j.molcel.2017.10.028. Epub 2017 Nov 16.
10
An aberrant phase transition of stress granules triggered by misfolded protein and prevented by chaperone function.由错误折叠的蛋白质引发并被伴侣功能阻止的应激颗粒异常相变。
EMBO J. 2017 Jun 14;36(12):1669-1687. doi: 10.15252/embj.201695957. Epub 2017 Apr 4.