综述：蛋白聚集病中的小胶质细胞：是敌是友？
Review: microglia in protein aggregation disorders: friend or foe?
机构信息
Neuropathology Unit, Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK.
出版信息
Neuropathol Appl Neurobiol. 2013 Feb;39(1):45-50. doi: 10.1111/nan.12017.
Abstract
Microglia cells have been implicated, to some extent, in the pathogenesis of all of the common neurodegenerative disorders involving protein aggregation such as Alzheimer's disease, Parkinson's disease and Amyotrophic Lateral Sclerosis. However, the precise role they play in the development of the pathologies remains unclear and it seems that they contribute to the pathological process in different ways depending on the specific disorder. A better understanding of their varied roles is essential if they are to be the target for novel therapeutic strategies.
摘要
小胶质细胞在一定程度上与所有涉及蛋白聚集的常见神经退行性疾病的发病机制有关，如阿尔茨海默病、帕金森病和肌萎缩侧索硬化症。然而，它们在病理发展过程中的确切作用尚不清楚，而且它们似乎根据特定的疾病以不同的方式促进病理过程。如果要将它们作为新的治疗策略的靶点，那么更好地了解它们的各种作用是至关重要的。
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