Lee Jeeun, Kim Ahwon, Choi Seok-Jin, Cho Eric, Seo Jaeyoung, Oh Seong-Il, Jung Jinho, Kim Ji-Sun, Sung Jung-Joon, Abrahams Sharon, Hong Yoon-Ho
Department of Neurology, Myongji Hospital, Hanyang University College of Medicine, Goyang, Korea.
Department of Neurology, Seoul National University Hospital, Seoul, Korea.
J Clin Neurol. 2023 Sep;19(5):454-459. doi: 10.3988/jcn.2022.0403. Epub 2023 Jul 20.
Cognitive and behavioral changes are common in amyotrophic lateral sclerosis (ALS), with about 15% of patients presenting with overt frontotemporal dementia and 30%-50% with varying degrees of impairments. We aimed to develop and validate the Korean version of the Edinburgh Cognitive and Behavioral ALS Screen (ECAS-K), a brief multidomain assessment tool developed for ALS patients with physical disability.
We developed the ECAS-K according to the translation guidelines, and administered it to 38 patients with ALS and 26 age- and education-level-matched controls. We also administered the Montreal Cognitive Assessment (MoCA) and Frontal Assessment Battery (FAB) to investigate convergent validity, and the Center for Neurologic Study-Liability Scale to assess the association between pseudobulbar affect and cognitive/behavioral changes.
Internal consistency among the ECAS-K test items was found to be high, with a Cronbach's alpha of 0.87. Significant differences were found between patients with ALS and the controls in language, fluency, and memory functions (<0.05). Abnormal performance based on the ECAS total score was noted in 39.4% of patients, and 66.6% presented behavioral changes in at least one domain. Significant correlations were observed between the scores of the ECAS-K and those of other cognitive screening tools (MoCA and FAB, with correlation coefficients of 0.69 and 0.55, respectively; <0.01).
We developed and validated the ECAS-K which could be used as an effective tool to screen the cognitive and behavioral impairments in Korean patients with ALS.
认知和行为改变在肌萎缩侧索硬化症（ALS）中很常见，约15%的患者表现为明显的额颞叶痴呆，30%-50%的患者有不同程度的损害。我们旨在开发并验证爱丁堡认知与行为ALS筛查量表韩语版（ECAS-K），这是一种为身体残疾的ALS患者开发的简短多领域评估工具。
我们根据翻译指南开发了ECAS-K，并将其应用于38例ALS患者和26例年龄及教育水平匹配的对照者。我们还应用了蒙特利尔认知评估量表（MoCA）和额叶评估量表（FAB）来研究聚合效度，并应用神经学研究易感性量表来评估假性球麻痹情感与认知/行为改变之间的关联。
发现ECAS-K测试项目之间的内部一致性较高，克朗巴哈系数为0.87。ALS患者与对照者在语言、流畅性和记忆功能方面存在显著差异（<0.05）。根据ECAS总分，39.4%的患者表现异常，66.6%的患者至少在一个领域出现行为改变。观察到ECAS-K得分与其他认知筛查工具（MoCA和FAB）得分之间存在显著相关性（相关系数分别为0.69和0.55；<0.01）。
我们开发并验证了ECAS-K，它可作为筛查韩国ALS患者认知和行为损害的有效工具。
