Jung Sohee, Jung Gucheol, Kim Dayoung, Oh Jeeyoung, Choi Kyomin
Department of Medical Artificial Intelligence, Deepnoid, Inc., Seoul, Korea.
Department of Neurology, College of Medicine, Konkuk University Medical Center, Seoul, Korea.
J Clin Neurol. 2023 Nov;19(6):558-564. doi: 10.3988/jcn.2023.0007. Epub 2023 Jul 20.
We performed a population-based study to determine the prevalence and incidence of chronic inflammatory demyelinating polyneuropathy (CIDP) in South Korea using data from the Korean Health Insurance Review and Assessment Service (HIRA) database.
Data recorded in the HIRA database between January 2016 and December 2020 were analyzed. The inclusion criteria in this study for patients with CIDP were a diagnostic code of G61.8 in the seventh and eighth revision of the Korean Standard Classification of Disease and a >3-month history of oral immunosuppressant use. The age-adjusted incidence rate and prevalence of CIDP in South Korea were also analyzed.
CIDP was newly diagnosed in 953 patients during the study period. The mean age at diagnosis was 58.36 years, and the male-to-female ratio was 1.74. The age-adjusted incidence rates were 0.22, 0.21, 0.23, 0.30, and 0.25 per 100,000 person-years in 2016, 2017, 2018, 2019, and 2020, respectively. The age-adjusted prevalence was estimated at 1.16 per 100,000 persons in 2020. Age and the Elixhauser Comorbidity Index were associated with the in-hospital mortality of patients with CIDP. Infection and cardiovascular disease (CVD) were also significantly associated with the in-hospital mortality of those patients. Acute-onset CIDP was initially diagnosed in an estimated 101 out of 953 patients with CIDP.
The prevalence and incidence rates of CIDP in South Korea were comparable between this nationwide cohort study and previous studies. Common comorbidities such as CVD and diabetes should be appropriately monitored in patients with CIDP to prevent a poor prognosis and socioeconomic burden.
我们利用韩国健康保险审查与评估服务（HIRA）数据库的数据进行了一项基于人群的研究，以确定韩国慢性炎性脱髓鞘性多发性神经病（CIDP）的患病率和发病率。
分析了HIRA数据库在2016年1月至2020年12月期间记录的数据。本研究中CIDP患者的纳入标准为韩国疾病标准分类第七版和第八版中的诊断代码G61.8以及口服免疫抑制剂使用史超过3个月。还分析了韩国CIDP的年龄调整发病率和患病率。
在研究期间，953例患者被新诊断为CIDP。诊断时的平均年龄为58.36岁，男女比例为1.74。2016年、2017年、2018年、2019年和2020年的年龄调整发病率分别为每10万人年0.22、0.21、0.23、0.30和0.25。2020年年龄调整患病率估计为每10万人1.16。年龄和埃利克斯豪泽合并症指数与CIDP患者的住院死亡率相关。感染和心血管疾病（CVD）也与这些患者的住院死亡率显著相关。在953例CIDP患者中，估计有101例最初被诊断为急性起病CIDP。
在这项全国性队列研究中，韩国CIDP的患病率和发病率与先前的研究相当。对于CIDP患者，应适当监测常见合并症，如CVD和糖尿病，以防止预后不良和社会经济负担。
