Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, People's Republic of China.
School of Nursing, Suzhou Medical College of Soochow University, Suzhou, People's Republic of China.
Int J Chron Obstruct Pulmon Dis. 2023 Jul 19;18:1525-1532. doi: 10.2147/COPD.S396728. eCollection 2023.
This study was designed to investigate the differences in skeletal-muscle atrophy between patients with stable chronic obstructive pulmonary disease (COPD) and healthy controls; associated factors were also considered. The study comprised selected residents of communities near the First Affiliated Hospital of Soochow University in Suzhou City, East China.
Included in this study were 123 COPD patients and 60 controls. All patients completed spirometry as well as examinations to determine their functional exercise capacity, body composition, and handgrip strength (HGS).
COPD patients had less fat-free mass (FFM), a lower FFM index (FFMI), and a lower 6-min walking distance (6MWD) compared with controls ( = 0.007, = 0.020, and < 0.001, respectively) (FFMI: 17.59 ± 1.83 vs 18.34 ± 1.64). The HGS of these patients was also lower compared with that of controls (32.88 ± 7.84 vs 35.48 ± 7.42), and HGS tended toward statistical significance ( = 0.064, respectively). In multivariate analysis, age (β = -0.107, < 0.001), gender (β = 0.212, < 0.001), body mass index (BMI) (β = 0.462, < 0.001), FEV% (β = 0.108, = 0.009), and calf circumference (CC) (β = 0.457, < 0.001) were significantly associated with FFMI.
Impaired skeletal muscle mass was more common in COPD patients than in controls. Multiple regression analysis showed that CC may be used to detect the degree of impairment, particularly by health-care providers working outside of the hospital.
本研究旨在探讨稳定期慢性阻塞性肺疾病（COPD）患者与健康对照者之间骨骼肌萎缩的差异，并考虑相关因素。该研究纳入了中国东部苏州市第一附属医院附近社区的部分居民。
本研究纳入了 123 例 COPD 患者和 60 例对照者。所有患者均完成了肺功能检查以及功能运动能力、身体成分和握力（HGS）检查。
与对照组相比，COPD 患者的去脂体重（FFM）更少，FFM 指数（FFMI）更低，6 分钟步行距离（6MWD）更短（P=0.007、P=0.020 和 P＜0.001）（FFMI：17.59±1.83 与 18.34±1.64）。这些患者的 HGS 也低于对照组（32.88±7.84 与 35.48±7.42），且具有统计学意义（P=0.064）。在多变量分析中，年龄（β=-0.107，P＜0.001）、性别（β=0.212，P＜0.001）、体质指数（BMI）（β=0.462，P＜0.001）、FEV%（β=0.108，P=0.009）和小腿围（CC）（β=0.457，P＜0.001）与 FFMI 显著相关。
与对照组相比，COPD 患者的骨骼肌质量受损更为常见。多元回归分析显示，CC 可用于检测受损程度，特别是在医院外工作的卫生保健提供者。
