Zhu Kongju, Spaink Herman P, Durston Antony J
Institute of Biology, Leiden University, Sylviusweg 72, 2333BE Leiden, The Netherlands.
Department of Pathology, Brigham and Women's Hospital, 60 Fenwood Road, Boston, MA 02115, USA.
J Dev Biol. 2023 Jul 3;11(3):31. doi: 10.3390/jdb11030031.
How head patterning is regulated in vertebrates is yet to be understood. In this study, we show that frog embryos injected with Noggin at different blastula and gastrula stages had their head development sequentially arrested at different positions. When timed BMP inhibition was applied to BMP-overexpressing embryos, the expression of five genes: (a marker of the cement gland, which is the front-most structure in the frog embryo), (a forebrain marker), (a forebrain and mid-brain marker), (an anterior hindbrain marker), and (a posterior hindbrain marker) were sequentially fixed. These results suggest that the vertebrate head is patterned from anterior to posterior in a progressive fashion and may involve timed actions of the BMP signaling.
脊椎动物头部模式是如何调控的尚未可知。在本研究中，我们发现，在不同囊胚期和原肠胚期注射Noggin的青蛙胚胎，其头部发育在不同位置依次停止。当对过表达BMP的胚胎进行定时BMP抑制时，五个基因的表达：（蛙胚胎中最前端结构——鼻腺的标志物）、（前脑标志物）、（前脑和中脑标志物）、（后脑前部标志物）和（后脑后部标志物）被依次固定。这些结果表明，脊椎动物的头部是以渐进方式从前向后形成模式的，可能涉及BMP信号的定时作用。
