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星形细胞和 NMDA 受体依赖性内向慢电流以年龄依赖的方式不同地贡献于小鼠和人新皮层中的突触可塑性。

Astrocyte- and NMDA receptor-dependent slow inward currents differently contribute to synaptic plasticity in an age-dependent manner in mouse and human neocortex.

机构信息

Department of Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Doctoral School of Molecular Medicine, University of Debrecen, Debrecen, Hungary.

出版信息

Aging Cell. 2023 Sep;22(9):e13939. doi: 10.1111/acel.13939. Epub 2023 Jul 25.

DOI:10.1111/acel.13939
PMID:37489544
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10497838/
Abstract

Slow inward currents (SICs) are known as excitatory events of neurons elicited by astrocytic glutamate via activation of extrasynaptic NMDA receptors. By using slice electrophysiology, we tried to provide evidence that SICs can elicit synaptic plasticity. Age dependence of SICs and their impact on synaptic plasticity was also investigated in both on murine and human cortical slices. It was found that SICs can induce a moderate synaptic plasticity, with features similar to spike timing-dependent plasticity. Overall SIC activity showed a clear decline with aging in humans and completely disappeared above a cutoff age. In conclusion, while SICs contribute to a form of astrocyte-dependent synaptic plasticity both in mice and humans, this plasticity is differentially affected by aging. Thus, SICs are likely to play an important role in age-dependent physiological and pathological alterations of synaptic plasticity.

摘要

慢内向电流（SICs）被认为是星形胶质细胞谷氨酸通过激活突触外 NMDA 受体引起神经元兴奋的事件。通过使用切片电生理学，我们试图提供证据表明 SICs 可以引发突触可塑性。我们还在小鼠和人类皮质切片中研究了 SICs 的年龄依赖性及其对突触可塑性的影响。结果发现，SICs 可以诱导适度的突触可塑性，其特征类似于尖峰时间依赖性可塑性。总的来说，SIC 活性在人类中随着年龄的增长而明显下降，在超过截止年龄后完全消失。总之，虽然 SICs 在小鼠和人类中都有助于一种星形胶质细胞依赖性的突触可塑性，但这种可塑性受到年龄的不同影响。因此，SICs 可能在年龄相关的突触可塑性的生理和病理改变中发挥重要作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cb1/10497838/3cf810ff52d3/ACEL-22-e13939-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cb1/10497838/34e4df6e75f1/ACEL-22-e13939-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cb1/10497838/e48dbdcf399d/ACEL-22-e13939-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cb1/10497838/33b0703fc89d/ACEL-22-e13939-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cb1/10497838/218b2f424f21/ACEL-22-e13939-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cb1/10497838/8263960fd82f/ACEL-22-e13939-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cb1/10497838/262187942397/ACEL-22-e13939-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cb1/10497838/3cf810ff52d3/ACEL-22-e13939-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cb1/10497838/34e4df6e75f1/ACEL-22-e13939-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cb1/10497838/e48dbdcf399d/ACEL-22-e13939-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cb1/10497838/33b0703fc89d/ACEL-22-e13939-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cb1/10497838/218b2f424f21/ACEL-22-e13939-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cb1/10497838/8263960fd82f/ACEL-22-e13939-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cb1/10497838/262187942397/ACEL-22-e13939-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cb1/10497838/3cf810ff52d3/ACEL-22-e13939-g001.jpg

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