Shandong University of Traditional Chinese Medicine, Jinan, China.
Central Laboratory, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
Scand J Immunol. 2023 May;97(5):e13265. doi: 10.1111/sji.13265. Epub 2023 Mar 26.
Aplastic anaemia (AA) is an autoimmune disease characterized by haematopoietic failure in the bone marrow. Abnormal activation and hyperfunction of T lymphocytes are believed to cause bone marrow damage, which plays a major role in AA pathogenesis. Dendritic cells (DCs) play a vital role in the immune system by processing antigens for presentation to T cells and regulating their differentiation and function. DC dysfunction may cause abnormal T-cell activation. Recent studies have associated the occurrence and development of AA with DC function. In this review, we have discussed the role of DCs in AA pathogenesis and their potential as putative therapeutic targets for AA.
再生障碍性贫血（AA）是一种以骨髓造血功能衰竭为特征的自身免疫性疾病。异常激活和功能亢进的 T 淋巴细胞被认为会导致骨髓损伤，这在 AA 的发病机制中起着主要作用。树突状细胞（DC）在免疫系统中起着至关重要的作用，它可以处理抗原并呈递给 T 细胞，调节其分化和功能。DC 功能障碍可能导致 T 细胞异常激活。最近的研究将 AA 的发生和发展与 DC 功能联系起来。在这篇综述中，我们讨论了 DC 在 AA 发病机制中的作用及其作为 AA 潜在治疗靶点的潜力。
