Fujian Key Laboratory of Intelligent Machining Technology and Equipment (Fujian University of Technology), Fuzhou 350118, China.
State Key Laboratory of Mechanical Manufacturing Systems Engineering, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, China.
ACS Biomater Sci Eng. 2023 Aug 14;9(8):5084-5096. doi: 10.1021/acsbiomaterials.3c00214. Epub 2023 Jul 25.
Titanium alloy porous scaffolds possess excellent mechanical properties and biocompatibility, making them promising for applications in bone tissue engineering. The integration of triply periodic minimal surface (TPMS) with porous scaffolds provides a structural resemblance to the trabecular and cortical bone structures of natural bone tissue, effectively reducing stress-shielding effects, enabling the scaffold to withstand complex stress environments, and facilitating nutrient transport. In this study, we designed fused porous scaffolds based on the Gyroid and Diamond units within TPMS and fabricated samples using selective laser melting technology. The effects of the rotation direction and angle of the inner-layer G unit on the elastic modulus of the fused TPMS porous scaffold were investigated through quasi-static compression experiments. Furthermore, the influence of the rotation direction and angle of the inner-layer G unit on the permeability, pressure, and flow velocity of the fused TPMS porous scaffold structure was studied using computational fluid dynamics (CFD) based on the Navier-Stokes model. The quasi-static compression experiment results demonstrated that the yield strength of the fused TPMS porous scaffold ranged from 367.741 to 419.354 MPa, and the elastic modulus ranged from 10.617 to 11.252 GPa, exhibiting stable mechanical performance in different loading directions. The CFD simulation results indicated that the permeability of the fused TPMS porous scaffold model ranged from 5.70015 × 10 to 6.33725 × 10 m. It can be observed that the fused porous scaffold meets the requirements of the complex stress-bearing demands of skeletal structures and complies with the permeability requirements of human bone tissue.
钛合金多孔支架具有优异的机械性能和生物相容性,有望在骨组织工程中得到应用。将三重周期性极小曲面(TPMS)与多孔支架结合,为多孔支架提供了类似于天然骨组织的小梁和皮质骨结构的结构相似性,有效降低了应力屏蔽效应,使支架能够承受复杂的应力环境,并促进营养物质的运输。在这项研究中,我们设计了基于 TPMS 中的 Gyroid 和 Diamond 单元的融合多孔支架,并使用选择性激光熔化技术制造了样品。通过准静态压缩实验研究了内层 G 单元的旋转方向和角度对融合 TPMS 多孔支架弹性模量的影响。此外,通过基于纳维-斯托克斯模型的计算流体动力学(CFD)研究了内层 G 单元的旋转方向和角度对融合 TPMS 多孔支架结构的渗透性、压力和流速的影响。准静态压缩实验结果表明,融合 TPMS 多孔支架的屈服强度在 367.741 到 419.354 MPa 之间,弹性模量在 10.617 到 11.252 GPa 之间,在不同的加载方向上表现出稳定的力学性能。CFD 模拟结果表明,融合 TPMS 多孔支架模型的渗透率在 5.70015×10 到 6.33725×10 m 之间。可以观察到,融合多孔支架满足骨骼结构复杂承载需求的要求,并符合人体骨组织的渗透率要求。