Ma Jiaqi, Li Yumeng, Mi Yujing, Gong Qiannan, Zhang Pengfei, Meng Bing, Wang Jue, Wang Jing, Fan Yawei
Department of Oral and Maxillofacial Surgery, First Hospital of Shanxi Medical University, Taiyuan, China.
Department of Orthodontics, First Hospital of Shanxi Medical University, Taiyuan, China.
J Tissue Eng. 2024 Jul 26;15:20417314241263689. doi: 10.1177/20417314241263689. eCollection 2024 Jan-Dec.
Bone defect disease seriously endangers human health and affects beauty and function. In the past five years, the three dimension (3D) printed radially graded triply periodic minimal surface (TPMS) porous scaffold has become a new solution for repairing bone defects. This review discusses 3D printing technologies and applications for TPMS scaffolds. To this end, the microstructural effects of 3D printed TPMS scaffolds on bone regeneration were reviewed and the structural characteristics of TPMS, which can promote bone regeneration, were introduced. Finally, the challenges and prospects of using TPMS scaffolds to treat bone defects were presented. This review is expected to stimulate the interest of bone tissue engineers in radially graded TPMS scaffolds and provide a reliable solution for the clinical treatment of personalised bone defects.
骨缺损疾病严重危害人类健康,影响美观和功能。在过去五年中,三维(3D)打印的径向渐变三重周期极小曲面(TPMS)多孔支架已成为修复骨缺损的新解决方案。本文综述了3D打印技术及其在TPMS支架中的应用。为此,回顾了3D打印TPMS支架对骨再生的微观结构影响,并介绍了可促进骨再生的TPMS结构特征。最后,阐述了使用TPMS支架治疗骨缺损面临的挑战和前景。本文有望激发骨组织工程领域研究人员对径向渐变TPMS支架的兴趣,并为个性化骨缺损的临床治疗提供可靠的解决方案。