Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States of America.
PLoS Biol. 2023 Jul 25;21(7):e3002226. doi: 10.1371/journal.pbio.3002226. eCollection 2023 Jul.
Microglia play a dual role in stroke depending on their pro-inflammatory and anti-inflammatory polarization. A study in PLOS Biology identifies a new mechanism, through which the transcription factor NR4A1 negatively regulates TNF expression in microglia.
小胶质细胞在中风中发挥双重作用，取决于它们的促炎和抗炎极化。PLOS Biology 的一项研究确定了一种新的机制，转录因子 NR4A1 通过该机制负向调节小胶质细胞中的 TNF 表达。
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