Division of Clinical Infectious Diseases, Research Center Borstel, Borstel, Germany; German Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Borstel, Germany; Respiratory Medicine & International Health, University of Lübeck, Lübeck, Germany; Department of Infectious Disease, Faculty of Medicine, Imperial College London, London, United Kingdom.
Emerging Bacterial Pathogens Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Clin Microbiol Infect. 2024 Sep;30(9):1115-1122. doi: 10.1016/j.cmi.2023.07.014. Epub 2023 Jul 23.
Tuberculosis (TB) remains a global public health threat, and the development of rapid and precise diagnostic tools is the key to enabling the early start of treatment, monitoring response to treatment, and preventing the spread of the disease.
An overview of recent progress in host- and pathogen-based TB diagnostics.
We conducted a PubMed search of recent relevant articles and guidelines on TB screening and diagnosis.
An overview of currently used methods and perspectives in the following areas of TB diagnostics is provided: immune-based diagnostics, X-ray, clinical symptoms and scores, cough detection, culture of Mycobacterium tuberculosis and identifying its resistance profile using phenotypic and genotypic methods, including next-generation sequencing, sputum- and non-sputum-based molecular diagnosis of TB and monitoring of response to treatment.
A brief overview of the most relevant advances and changes in international guidelines regarding screening and diagnosing TB is provided in this review. It aims at reviewing all relevant areas of diagnostics, including both pathogen- and host-based methods.
结核病（TB）仍然是全球公共卫生威胁，开发快速而精确的诊断工具是实现早期治疗、监测治疗反应和防止疾病传播的关键。
概述基于宿主和病原体的结核病诊断的最新进展。
我们对最近关于结核病筛查和诊断的相关文章和指南进行了 PubMed 检索。
本文概述了目前用于以下领域的方法和观点：免疫诊断、X 射线、临床症状和评分、咳嗽检测、分枝杆菌结核培养和使用表型和基因型方法（包括下一代测序）鉴定其耐药谱，包括痰液和非痰液的结核分子诊断和监测治疗反应。
本综述简要概述了国际指南中关于筛查和诊断结核病的最相关进展和变化。它旨在综述诊断的所有相关领域，包括基于病原体和宿主的方法。
