在纵向早发性阿尔茨海默病研究中的脑脊液生物标志物。
Cerebrospinal fluid biomarkers in the Longitudinal Early-onset Alzheimer's Disease Study.
机构信息
Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
出版信息
Alzheimers Dement. 2023 Nov;19 Suppl 9(Suppl 9):S115-S125. doi: 10.1002/alz.13399. Epub 2023 Jul 25.
INTRODUCTION
One goal of the Longitudinal Early Onset Alzheimer's Disease Study (LEADS) is to define the fluid biomarker characteristics of early-onset Alzheimer's disease (EOAD).
METHODS
Cerebrospinal fluid (CSF) concentrations of Aβ1-40, Aβ1-42, total tau (tTau), pTau181, VILIP-1, SNAP-25, neurogranin (Ng), neurofilament light chain (NfL), and YKL-40 were measured by immunoassay in 165 LEADS participants. The associations of biomarker concentrations with diagnostic group and standard cognitive tests were evaluated.
RESULTS
Biomarkers were correlated with one another. Levels of CSF Aβ42/40, pTau181, tTau, SNAP-25, and Ng in EOAD differed significantly from cognitively normal and early-onset non-AD dementia; NfL, YKL-40, and VILIP-1 did not. Across groups, all biomarkers except SNAP-25 were correlated with cognition. Within the EOAD group, Aβ42/40, NfL, Ng, and SNAP-25 were correlated with at least one cognitive measure.
DISCUSSION
This study provides a comprehensive analysis of CSF biomarkers in sporadic EOAD that can inform EOAD clinical trial design.
简介
纵向早发性阿尔茨海默病研究（LEADS）的目标之一是定义早发性阿尔茨海默病（EOAD）的液体生物标志物特征。
方法
通过免疫测定法测量了 165 名 LEADS 参与者的脑脊液（CSF）中 Aβ1-40、Aβ1-42、总 tau（tTau）、pTau181、VILIP-1、SNAP-25、神经颗粒蛋白（Ng）、神经丝轻链（NfL）和 YKL-40 的浓度。评估了生物标志物浓度与诊断组和标准认知测试的相关性。
结果
生物标志物相互关联。EOAD 组的 CSF Aβ42/40、pTau181、tTau、SNAP-25 和 Ng 水平与认知正常和早发性非 AD 痴呆显著不同；NfL、YKL-40 和 VILIP-1 则不然。在所有组中，除了 SNAP-25 之外，所有生物标志物都与认知相关。在 EOAD 组中，Aβ42/40、NfL、Ng 和 SNAP-25 与至少一项认知测量相关。
讨论
本研究对散发性 EOAD 的 CSF 生物标志物进行了全面分析，可为 EOAD 临床试验设计提供信息。
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