Hammers Dustin B, Eloyan Ani, Thangarajah Maryanne, Taurone Alexander, Beckett Laurel, Gao Sujuan, Polsinelli Angelina J, Kirby Kala, Dage Jeffrey L, Nudelman Kelly, Aisen Paul, Reman Rema, La Joie Renaud, Lagarde Julien, Atri Alireza, Clark David, Day Gregory S, Duara Ranjan, Graff-Radford Neill R, Honig Lawrence S, Jones David T, Masdeu Joseph C, Mendez Mario F, Womack Kyle, Musiek Erik, Onyike Chiadi U, Riddle Meghan, Grant Ian, Rogalski Emily, Johnson Erik C B, Salloway Steven, Sha Sharon J, Turner Raymond Scott, Wingo Thomas S, Wolk David A, Carrillo Maria C, Dickerson Bradford C, Rabinovici Gil D, Apostolova Liana G
Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Department of Biostatistics, Center for Statistical Sciences, Brown University, Providence, Rhode Island, USA.
Alzheimers Dement. 2025 Jan;21(1):e14218. doi: 10.1002/alz.14218. Epub 2024 Dec 23.
Early-onset Alzheimer's disease (EOAD) and late-onset Alzheimer's disease (LOAD) share similar amyloid etiology, but evidence from smaller-scale studies suggests that they manifest differently clinically. Current analyses sought to contrast the cognitive profiles of EOAD and LOAD.
Z-score cognitive-domain composites for 311 amyloid-positive sporadic EOAD and 314 amyloid-positive LOAD participants were calculated from baseline data from age-appropriate control cohorts. Z-score composites were compared between AD groups for each domain.
After controlling for cognitive status, EOAD displayed worse visuospatial, executive functioning, and processing speed/attention skills relative to LOAD, and LOAD displayed worse language, episodic immediate memory, and episodic delayed memory.
Sporadic EOAD possesses distinct cognitive profiles relative to LOAD. Clinicians should be alert for non-amnestic impairments in younger patients to ensure proper identification and intervention using disease-modifying treatments.
Both early-onset Alzheimer's disease (EOAD) and late-onset Alzheimer's disease (LOAD) participants displayed widespread cognitive impairments relative to their same-aged peers. Cognitive impairments were more severe for EOAD than for LOAD participants in visuospatial and executive domains. Memory and language impairments were more severe for LOAD than for EOAD participants Results were comparable after removing clinical phenotypes of posterior cortical atrophy (PCA), primary progressive aphasia (lv-PPA), and frontal-variant AD.
早发性阿尔茨海默病（EOAD）和晚发性阿尔茨海默病（LOAD）具有相似的淀粉样蛋白病因，但小规模研究的证据表明它们在临床上表现不同。当前的分析旨在对比EOAD和LOAD的认知特征。
根据年龄匹配的对照队列的基线数据，计算了311名淀粉样蛋白阳性散发性EOAD参与者和314名淀粉样蛋白阳性LOAD参与者的Z评分认知领域综合得分。对每个领域的AD组之间的Z评分综合得分进行了比较。
在控制认知状态后，相对于LOAD，EOAD在视觉空间、执行功能以及处理速度/注意力技能方面表现更差，而LOAD在语言、情景即时记忆和情景延迟记忆方面表现更差。
散发性EOAD相对于LOAD具有独特的认知特征。临床医生应警惕年轻患者的非遗忘性损害，以确保使用疾病修饰治疗进行正确的识别和干预。
早发性阿尔茨海默病（EOAD）和晚发性阿尔茨海默病（LOAD）参与者相对于同龄人都表现出广泛的认知障碍。在视觉空间和执行领域，EOAD参与者的认知障碍比LOAD参与者更严重。LOAD参与者的记忆和语言障碍比EOAD参与者更严重。去除后皮质萎缩（PCA）、原发性进行性失语（lv-PPA）和额颞叶变性型AD的临床表型后，结果具有可比性。
