Maternal Fetal Medicine Division, Department of Obstetrics and Gynecology at The Ohio State University, Columbus, Ohio, USA.
Department of Pediatrics, Nationwide Children's Hospital, Ohio State University College of Medicine, Columbus, Ohio, USA.
Am J Reprod Immunol. 2023 Aug;90(2):e13742. doi: 10.1111/aji.13742.
Transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from infected pregnant individuals to the fetus or newborn occurs from 1.2% to 4.3%. Our aim was to determine the rate of positivity among newborns delivered to infected mothers during epochs of different variants predominance.
This is a single academic center retrospective cohort study where we reviewed the electronic health records of pregnant individuals who tested positive for SARS-CoV-2 infection and their newborns from March 2020 through January 2022. Infants born to SARS-CoV-2-positive mothers at the time of delivery or within 10 days of admission were tested for SARS-CoV-2 infection at 24-36 h of age.
A total of 195 mothers were positive at delivery or within 10 days of admission and had their newborns tested for SARS-CoV-2. Seven newborns (3.6%) were positive. All positive infants were asymptomatic and born to unvaccinated mothers. Newborn positivity for SARS-CoV-2 was highest during the Omicron epoch (9.4%, p = .01).
Increasing positivity rate was seen during the Omicron variant predominance. This could be attributed to postnatal acquisition of the virus, as Omicron has been associated with higher transmissibility in older children and adults.
感染 SARS-CoV-2 的孕妇将病毒传染给胎儿或新生儿的概率为 1.2%至 4.3%。我们的目的是确定在不同变体为主导的时期，感染母亲所生新生儿的阳性率。
这是一项单中心回顾性队列研究，我们回顾了 2020 年 3 月至 2022 年 1 月期间 SARS-CoV-2 感染检测呈阳性的孕妇及其新生儿的电子健康记录。在分娩时或住院后 10 天内 SARS-CoV-2 阳性的母亲所生的婴儿，在出生后 24-36 小时接受 SARS-CoV-2 感染检测。
共有 195 名母亲在分娩时或住院后 10 天内检测出 SARS-CoV-2 阳性，并对其新生儿进行了 SARS-CoV-2 检测。有 7 名新生儿（3.6%）呈阳性。所有阳性婴儿均无症状，且均出生于未接种疫苗的母亲。在 Omicron 变体为主导的时期，SARS-CoV-2 的阳性率最高（9.4%，p=0.01）。
在 Omicron 变体为主导的时期，阳性率呈上升趋势。这可能归因于病毒的产后获得，因为 Omicron 与儿童和成人的更高传染性有关。
