Muir J L, Brown R, Pfister H P
Pharmacol Biochem Behav. 1986 Jul;25(1):107-10. doi: 10.1016/0091-3057(86)90238-8.
Recent evidence suggests that oxytocin (OXT) potentiates corticotropin releasing factor-induced secretion of ACTH. The present study was therefore designed to investigate the possible role of oxytocin in the response to predictable and unpredictable novelty stress. The results clearly demonstrate that oxytocin produced a significant increase in corticosterone in all OXT treated animals. Repeated unpredictable exposure also produced a more substantial increase in corticosterone than predictable exposure to the same stressor. However, a significant interaction between stress and oxytocin was not obtained. It was concluded that whereas corticosterone is released in response to most types of stress, administration of oxytocin does not potentiate the corticosterone response to psychological stress.
最近的证据表明，催产素（OXT）可增强促肾上腺皮质激素释放因子诱导的促肾上腺皮质激素（ACTH）分泌。因此，本研究旨在探讨催产素在对可预测和不可预测的新异应激反应中的可能作用。结果清楚地表明，催产素使所有接受OXT治疗的动物的皮质酮显著增加。反复不可预测的暴露也比可预测的相同应激源暴露使皮质酮增加得更多。然而，未获得应激与催产素之间的显著相互作用。得出的结论是，虽然皮质酮会因大多数类型的应激而释放，但给予催产素并不会增强对心理应激的皮质酮反应。
