Department of Medicine, Jacobi Medical Center, Bronx, NY, 10461, USA.
Albert Einstein College of Medicine, Bronx, NY, 10461, USA.
Vasc Health Risk Manag. 2023 Jul 20;19:469-484. doi: 10.2147/VHRM.S404537. eCollection 2023.
Venous thromboembolism (VTE) is a serious medical condition that can lead to severe morbidity and mortality, making it a significant public health concern. VTE is a multifactorial condition that results from the interaction of genetic, acquired, and environmental factors. Physiological changes during pregnancy increase the risk of VTE as they express Virchow's triad (increased coagulation factors, decreased fibrinolysis, trauma, and venous stasis). Moreover, pregnancy-related risk factors, such as advanced maternal age, obesity, multiple gestations, and cesarean delivery, further increase the risk of VTE. Managing VTE in pregnancy is challenging due to the complexity of balancing the risks and benefits of anticoagulant therapy for both the mother and the fetus. A multidisciplinary approach involving obstetricians, hematologists, and neonatologists, is necessary to ensure optimal outcomes for both the mother and baby. This review aims to discuss the current challenges associated with VTE in pregnancy and identify potential solutions for improving outcomes for pregnant women at risk for VTE.
静脉血栓栓塞症（VTE）是一种严重的医疗状况，可导致严重的发病率和死亡率，因此成为一个重大的公共卫生关注点。VTE 是一种多因素病症，由遗传、获得性和环境因素相互作用所致。妊娠期间的生理变化会增加 VTE 的风险，因为这些变化会表达 Virchow 三联征（凝血因子增加、纤维蛋白溶解减少、创伤和静脉淤滞）。此外，妊娠相关的风险因素，如高龄产妇、肥胖、多胎妊娠和剖宫产，进一步增加了 VTE 的风险。由于需要平衡抗凝治疗对母亲和胎儿的风险和益处，妊娠期间管理 VTE 具有挑战性。涉及产科医生、血液科医生和新生儿科医生的多学科方法是必要的，以确保母亲和婴儿的最佳结局。本综述旨在讨论与妊娠相关的 VTE 相关的当前挑战，并确定改善有 VTE 风险的孕妇结局的潜在解决方案。
