Huang Junyang, Zhang Kun, Du Ruolin, Liu Wanling, Zhang Haijun, Tian Tian, Wang Yazhou, Wang Guixue, Yin Tieying
Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing 400030, China.
Department of Vascular & Intervention, Tenth Peoples' Hospital of Tongji University, Shanghai 200072, China.
Genes Dis. 2022 Sep 5;10(5):1956-1968. doi: 10.1016/j.gendis.2022.08.015. eCollection 2023 Sep.
In recent years, cardiovascular health problems are becoming more and more serious. At the same time, mechanical stimulation closely relates to cardiovascular health. In this context, Piezo1, which is very sensitive to mechanical stimulation, has attracted our attention. Here, we review the critical significance of Piezo1 in mechanical stimulation of endothelial cells, NO production, lipid metabolism, DNA damage protection, the development of new blood vessels and maturation, narrowing of blood vessels, blood pressure regulation, vascular permeability, insulin sensitivity, and maintenance of red blood cell function. Besides, Piezo1 may participate in the occurrence and development of atherosclerosis, diabetes, hypertension, and other cardiovascular diseases. It is worth noting that Piezo1 has dual effects on maintaining cardiovascular health. On the one hand, the function of Piezo1 is necessary to maintain cardiovascular health; on the other hand, under some extreme mechanical stimulation, the overexpression of Piezo1 may bring adverse factors such as inflammation. Therefore, this review discusses the Janus-faced role of Piezo1 in maintaining cardiovascular health and puts forward new ideas to provide references for gene therapy or nanoagents targeting Piezo1.
近年来，心血管健康问题日益严重。与此同时，机械刺激与心血管健康密切相关。在此背景下，对机械刺激非常敏感的Piezo1引起了我们的关注。在此，我们综述了Piezo1在内皮细胞机械刺激、一氧化氮生成、脂质代谢、DNA损伤保护、新血管发育与成熟、血管狭窄、血压调节、血管通透性、胰岛素敏感性以及红细胞功能维持等方面的关键意义。此外，Piezo1可能参与动脉粥样硬化、糖尿病、高血压等心血管疾病的发生发展。值得注意的是，Piezo1在维持心血管健康方面具有双重作用。一方面，Piezo1的功能对于维持心血管健康是必要的；另一方面，在某些极端机械刺激下，Piezo1的过度表达可能会带来炎症等不利因素。因此，本综述探讨了Piezo1在维持心血管健康中的双面作用，并提出新思路，为针对Piezo1的基因治疗或纳米制剂提供参考。
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