Shinge Shafiu A Umar, Zhang Daifang, Achu Muluh Tobias, Nie Yongmei, Yu Fengxu
Cardiovascular Surgery Department, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, People's Republic of China.
Clinical Research Center, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, People's Republic of China.
J Inflamm Res. 2021 Jul 27;14:3621-3636. doi: 10.2147/JIR.S319789. eCollection 2021.
Recently, more and more works have focused and used extensive resources on atherosclerosis research, which is one of the major causes of death globally. Alongside traditional risk factors, such as hyperlipidemia, smoking, hypertension, obesity, and diabetes, mechanical forces, including shear stress, pressure and stretches exerted on endothelial cells by flow, is proved to be crucial in atherosclerosis development. Studies have recognized the mechanosensitive Piezo1 channel as a special sensor and transducer of various mechanical forces into biochemical signals, and recent studies report its role in atherosclerosis through different mechanical forces in pressure, stretching and turbulent shear stress. Based on our expertise in this field and considering the recent advancement of atherosclerosis research, we will be focusing on the function of Piezo1 and its involvement in various cellular mechanisms and consequent involvement in the development of atherosclerosis in this review. Also, we will discuss various functions of Piezo1 involvement in atherosclerosis and come up with new mechanistic insight for future research. Based on the recent findings, we suggest Piezo1 as a valid candidate for novel therapeutic innovations, in which deep exploration and translating its findings into the clinic will be a new therapeutic strategy for cardiovascular diseases, particularly atherosclerosis.
最近，越来越多的研究致力于动脉粥样硬化的研究，并为此投入了大量资源，动脉粥样硬化是全球主要死因之一。除了高脂血症、吸烟、高血压、肥胖和糖尿病等传统风险因素外，包括血流对内皮细胞施加的剪切应力、压力和拉伸在内的机械力，被证明在动脉粥样硬化的发展中起着关键作用。研究已认识到机械敏感的Piezo1通道是将各种机械力转化为生化信号的特殊传感器和转换器，最近的研究报告了其在压力、拉伸和湍流剪切应力等不同机械力作用下在动脉粥样硬化中的作用。基于我们在该领域的专业知识，并考虑到动脉粥样硬化研究的最新进展，在本综述中，我们将重点关注Piezo1的功能及其在各种细胞机制中的参与情况，以及随之而来的在动脉粥样硬化发展中的参与情况。此外，我们将讨论Piezo1参与动脉粥样硬化的各种功能，并为未来研究提出新的机制见解。基于最近的研究结果，我们建议将Piezo1作为新型治疗创新的有效候选者，深入探索并将其研究结果转化为临床应用将是心血管疾病，特别是动脉粥样硬化的一种新的治疗策略。
