Paediatrics and Child Health, Cork University Hospital, Cork, Ireland.
INFANT Research Centre, University College Cork, Cork, Ireland.
Pediatr Allergy Immunol. 2023 Jul;34(7):e13998. doi: 10.1111/pai.13998.
Skin barrier dysfunction is a key component of the pathogenesis of atopic dermatitis (AD). Recent research on barrier optimization to prevent AD has shown mixed results. The aim of this study was to assess the relationship between emollient bathing at 2 months and the trajectory of AD in the first 2 years of life in a large unselected observational birth cohort study.
The Babies After SCOPE: Evaluating the Longitudinal Impact Using Neurological and Nutritional Endpoints Birth Cohort study enrolled 2183 infants. Variables extracted from the database related to early skincare, skin barrier function, parental history of atopy, and AD outcomes. Statistical analysis was performed to adjust for potential confounding variables.
One thousand five hundred five children had data on AD status available at 6, 12, and 24 months. Prevalence of AD was 18.6% at 6 months, 15.2% at 12 months, and 16.5% at 24 months. Adjusted for potential confounding variables, the odds of AD at any point were higher among infants who had emollient baths at 2 months (OR (95% CI): 2.41 (1.56 to 3.72), p < .001). Following multivariable analysis, the odds of AD were higher among infants who had both emollient baths and frequent emollient application at 2 months, compared with infants who had neither (OR (95% CI) at 6 months 1.74 (1.18-2.58), p = .038), (OR (95% CI) at 12 months 2.59 (1.69-3.94), p < .001), (OR (95% CI) at 24 months 1.87 (1.21-2.90), p = .009).
Early emollient bathing was associated with greater development of AD by 2 years of age in this population-based birth cohort study.
皮肤屏障功能障碍是特应性皮炎（AD）发病机制的关键组成部分。最近关于优化屏障以预防 AD 的研究结果喜忧参半。本研究旨在评估在一项大型未选择的观察性出生队列研究中，婴儿在 2 个月大时使用保湿剂沐浴与生命最初 2 年内 AD 轨迹之间的关系。
SCOPE 后婴儿：评估使用神经和营养终点的纵向影响出生队列研究纳入了 2183 名婴儿。从数据库中提取与早期皮肤护理、皮肤屏障功能、父母特应性史和 AD 结果相关的变量。进行统计分析以调整潜在的混杂变量。
1505 名儿童在 6、12 和 24 个月时有 AD 状态数据。6 个月时 AD 的患病率为 18.6%，12 个月时为 15.2%，24 个月时为 16.5%。调整潜在的混杂变量后，2 个月大时使用保湿剂沐浴的婴儿在任何时间点患 AD 的几率更高（OR（95%CI）：2.41（1.56 至 3.72），p<.001）。多变量分析后，与既不使用保湿剂沐浴也不经常使用保湿剂的婴儿相比，既使用保湿剂沐浴又经常使用保湿剂的婴儿患 AD 的几率更高（6 个月时 OR（95%CI）：1.74（1.18 至 2.58），p=.038），（12 个月时 OR（95%CI）：2.59（1.69 至 3.94），p<.001），（24 个月时 OR（95%CI）：1.87（1.21 至 2.90），p=.009）。
在这项基于人群的出生队列研究中，早期使用保湿剂沐浴与生命最初 2 年内 AD 的发展更为相关。
