Oregon Rural Practice Based Research Network, Oregon Health & Science University, Portland, Oregon, USA.
Center for Health Systems Effectiveness, Oregon Health & Science University, Portland, Oregon, USA.
Pediatr Dermatol. 2023 Nov-Dec;40(6):1042-1048. doi: 10.1111/pde.15449. Epub 2023 Oct 6.
Environmental factors such as bathing may play a role in atopic dermatitis (AD) development. This analysis utilized data from the Community Assessment of Skin Care, Allergies, and Eczema (CASCADE) Trial (NCT03409367), a randomized controlled trial of emollient therapy for AD prevention in the general population, to estimate bathing frequency and associated factors within the first 9 weeks of life.
Data were collected from 909 parent/newborn dyads recruited from 25 pediatric and family medicine clinics from the Meta-network Learning and Research Center (Meta-LARC) practice-based research network (PBRN) consortium in Oregon, North Carolina, Colorado, and Wisconsin for the CASCADE trial. Ordinal logistic regression was used to conduct a cross-sectional analysis of the association between bathing frequency (measured in baths per week) and demographic, medical, and lifestyle information about the infant, their family, and their household. Variables were selected using a backwards-stepwise method and estimates from the reduced model are reported in the text.
Moisturizer use (OR = 2.03, 95% CI: 1.54-2.68), Hispanic or Latino ethnicity (OR = 1.97, 95% CI: 1.42-2.72), a parental education level lower than a 4-year college degree (OR = 2.48, 95% CI: 1.70-3.62), living in North Carolina or Wisconsin (compared to Oregon; OR = 2.12 and 1.47, 95% CI: 1.53-2.93 and 1.04-2.08, respectively), and increasing child age (in days; OR = 1.02, 95% CI: 1.01-1.02) were significantly associated with more frequent bathing, while pet ownership (OR = 0.67, 95% CI: 0.52-0.87) was significantly associated with less frequent bathing.
We found significant ethnic, geographic, and socioeconomic variation in bathing frequency before 9 weeks of age that may be of relevance to AD prevention studies.
环境因素,如洗澡,可能在特应性皮炎(AD)的发病机制中起作用。本分析利用了社区皮肤护理、过敏和湿疹评估(CASCADE)试验(NCT03409367)的数据,该试验是一项针对普通人群 AD 预防的保湿剂治疗的随机对照试验,旨在估计生命的前 9 周内的洗澡频率及其相关因素。
该研究数据来自 Meta-network Learning and Research Center(Meta-LARC)实践基础研究网络(PBRN)联盟从俄勒冈州、北卡罗来纳州、科罗拉多州和威斯康星州的 25 家儿科和家庭医学诊所招募的 909 对父母/新生儿,他们参加了 CASCADE 试验。使用有序逻辑回归对洗澡频率(以每周洗澡次数衡量)与婴儿及其家庭和家庭的人口统计学、医学和生活方式信息之间的关联进行横断面分析。使用向后逐步法选择变量,并报告简化模型的估计值。
保湿剂使用(OR=2.03,95%CI:1.54-2.68)、西班牙裔或拉丁裔(OR=1.97,95%CI:1.42-2.72)、父母受教育程度低于四年制大学(OR=2.48,95%CI:1.70-3.62)、居住在北卡罗来纳州或威斯康星州(与俄勒冈州相比;OR=2.12 和 1.47,95%CI:1.53-2.93 和 1.04-2.08)和增加的儿童年龄(以天计;OR=1.02,95%CI:1.01-1.02)与更频繁的洗澡显著相关,而宠物拥有(OR=0.67,95%CI:0.52-0.87)与洗澡频率较低显著相关。
我们发现,在 9 周龄之前,洗澡频率存在显著的种族、地理和社会经济差异,这可能与 AD 预防研究相关。