Broekkamp C L, O'Connor W T, Tonnaer J A, Rijk H W, Van Delft A M
Physiol Behav. 1986;37(3):429-34. doi: 10.1016/0031-9384(86)90201-5.
Consequences of olfactory bulbectomy in two behavioural situations, passive avoidance acquisition and activity in a brightly lit open field, were measured in the same animals for which data on four biochemical measures were also obtained. The biochemical measurements were on plasma corticosterone levels, noradrenaline (NA) levels in the midbrain and amygdala + pyriform cortex and the choline acetyltransferase (CAT) levels in the olfactory tubercle. Experimental variation in age groups of rats (7 weeks and 3 months) and in post-bulbectomy periods (1, 2 and 4 weeks) was made. The deficit in passive avoidance as a consequence of olfactory bulbectomy was evident in all groups of young animals and in older animals one and two weeks post-bulbectomy but not in older animals four weeks after bulbectomy. An increase in open field activity was similarly observed in all groups except in the older animals four weeks after bulbectomy. In contrast to reports by other investigators the basal plasma corticosterone levels were not increased in bulbectomized animals nor did we observe any diminution of NA levels in the amygdala (+ pyriform cortex). CAT levels were slightly increased in older animals two weeks after bulbectomy. The absence of a change in the plasma corticosterone level after bulbectomy is discussed in relation to the notion that the olfactory bulbectomized rat is in some way relevant as a test model for predicting efficacy of potential antidepressant drugs.
在同一组动物中，测量了嗅球切除术后在两种行为情境下的后果，即被动回避学习和在明亮开阔场地中的活动情况，同时还获取了这组动物四项生化指标的数据。生化指标测量包括血浆皮质酮水平、中脑以及杏仁核 + 梨状皮质中的去甲肾上腺素（NA）水平，还有嗅结节中的胆碱乙酰转移酶（CAT）水平。对大鼠年龄组（7周龄和3月龄）以及嗅球切除术后时间段（1周、2周和4周）进行了实验性变动。嗅球切除导致的被动回避缺陷在所有幼龄动物组以及术后1周和2周的老龄动物中都很明显，但在术后4周的老龄动物中不明显。类似地，除了术后4周的老龄动物外，所有组的开阔场地活动都有所增加。与其他研究者的报告不同，嗅球切除动物的基础血浆皮质酮水平并未升高，我们也未观察到杏仁核（+ 梨状皮质）中NA水平有任何降低。老龄动物在嗅球切除术后2周时CAT水平略有升高。结合嗅球切除大鼠在某种程度上可作为预测潜在抗抑郁药物疗效的测试模型这一观点，讨论了嗅球切除术后血浆皮质酮水平无变化的情况。
