Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan.
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan; Institute for AI and Beyond, The University of Tokyo, Tokyo 113-0033, Japan; Center for Information and Neural Networks, National Institute of Information and Communications Technology, Suita City, Osaka 565-0871, Japan.
Cell Rep. 2023 Aug 29;42(8):112871. doi: 10.1016/j.celrep.2023.112871. Epub 2023 Jul 25.
Learning novel experiences reorganizes hippocampal neuronal circuits, represented as coordinated reactivation patterns in post-experience offline states for memory consolidation. This study examines how awake synchronous events during a novel run are related to post-run reactivation patterns. The disruption of awake sharp-wave ripples inhibited experience-induced increases in the contributions of neurons to post-experience synchronous events. Hippocampal place cells that participate more in awake synchronous events are more strongly reactivated during post-experience synchronous events. Awake synchronous neuronal patterns, in cooperation with place-selective firing patterns, determine cell ensembles that undergo pronounced increases and decreases in their correlated spikes. Taken together, awake synchronous events are fundamental for identifying hippocampal neuronal ensembles to be incorporated into synchronous reactivation during subsequent offline states, thereby facilitating memory consolidation.
学习新的经验会重新组织海马体神经元回路，表现为经验后离线状态下协调的再激活模式，以进行记忆巩固。本研究探讨了在新的运行期间清醒同步事件如何与运行后再激活模式相关。在清醒时抑制尖锐波涟漪的干扰会抑制经验引起的神经元对运行后同步事件的贡献增加。在经验后同步事件中，更多参与清醒同步事件的海马体位置细胞被强烈再激活。清醒同步神经元模式与位置选择的发射模式相结合，确定了经历明显增加和减少相关尖峰的细胞集合体。总的来说，清醒同步事件对于识别海马体神经元集合体以便在随后的离线状态下进行同步再激活是至关重要的，从而促进了记忆巩固。
