Institute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China; Liangzhu Laboratory, Zhejiang University Medical Center, 1369 West Wenyi Road, Hangzhou 311121, China; The Key Laboratory for Immunity and Inflammatory Diseases of Zhejiang Province, Hangzhou 310058, China.
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Biomed Pharmacother. 2023 Sep;165:115171. doi: 10.1016/j.biopha.2023.115171. Epub 2023 Jul 24.
The decoration of RNA with N-methyladenosine (mA) is a reversible post-transcriptional modification that plays an important regulatory role in all eukaryotic life activities. The mA modification of RNA regulates the development and progression of tumors, including bladder cancer, melanoma, Lewis lung carcinoma, and hepatocellular carcinoma. The tumor immune microenvironment (TIME) includes immune cells, cytokines, and cell surface molecules, which interact with each other and ultimately determine the flow of tumor immunity. The onset of cancer implies that the TIME has been reshaped into a pro-tumor state. The key to cancer treatment lies in reshaping the TIME to reset the anti-tumor immune response. Here, we have reviewed how RNA mA modification affects the TIME, and discussed the merits of using mA regulator inhibitors as an individual treatment strategy as well as in combination with immune checkpoint blockade therapy.
RNA 的 N6-甲基腺苷（m6A）修饰是一种可逆的转录后修饰，在所有真核生物的生命活动中发挥着重要的调控作用。RNA 的 m6A 修饰调控肿瘤的发生发展，包括膀胱癌、黑色素瘤、Lewis 肺癌和肝癌等。肿瘤免疫微环境（TIME）包括免疫细胞、细胞因子和细胞表面分子，它们相互作用，最终决定了肿瘤免疫的流向。癌症的发生意味着 TIME 已经被重塑为促肿瘤状态。癌症治疗的关键在于重塑 TIME，重新启动抗肿瘤免疫反应。在这里，我们综述了 RNA m6A 修饰如何影响 TIME，并讨论了使用 m6A 调节因子抑制剂作为单一治疗策略以及与免疫检查点阻断治疗联合应用的优点。
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